Phytochemistry, Pharmacology and Botanical Aspects of Hortia Species in the Search for Molecules with Bioactive Potential – A Review

Pharmacognosy Reviews,2021,14,28,97-105.
Published:February 2021
Type:Review Article
Author(s) affiliations:

Roberto Campos Portela1, Tatiana de Sousa Fiuza2, José Realino de Paula3,*, Leonardo Luiz Borges1,4

1Campus Henrique Santillo, Universidade Estadual de Goiás, Anápolis, GO, BRASIL.

2Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, BRASIL.

3Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, BRAZIL.

4Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BRASIL.


Hortia Vand. is a Neotropical genus of Rutaceae. Ten species occurs in South America in Atlantic forests, in Brazilian Savannah (Cerrado) and especially in the Amazon. Among these species, H. brasiliana is used to treat fevers, malaria, diarrhea, vomiting and liver diseases. H. oreadica is popularly use as antipyretic, substitute for quina, as tonic and stomach. This paper aims to give an overview of the Hortia genus, focusing on morphological, phytochemical and biological activities to stimulate new studies about these species. The main substances and derivatives isolated from Hortia species include dictamnine, γ-fagarine, skimmianine, robustine, flindersine, N-methyl-flindersine, rutaecarpine, hortiamine, hortiacine, seselin, 5-methoxyseselin, scoparon, guianin, limonin and nerolidol. These substances present properties such as antimicrobial, antifungal, anti-inflammatory, spasmolytic, anti-diabetic, anti-atherosclerotic, antiulcerogenic, anticancer, hepatoprotective, neuroprotective, immunosuppressive, antimalarial, acaricidal, larvicidal and antifeed. Several of these activities could justify the popular uses of the Hortia species.