Arthritis comes under the bandwagon of one of the most menacing diseases that are known to mankind and the more concerning matter is unavailability of permanent cure for this condition. The conditions of severe joint inflammation are being treated with conventional therapeutics that imparts a range of adverse effects, which prompted the researchers to look for safer options in the form of herbal medicines. Numerous plants, their parts, extracts, and their phyto-isolates have been explored till date for their anti-arthritic potential. However, there are risks of stability and delivery issues with these plant products, hence limiting their utility for effective therapy in the management of inflammatory diseases. Nanotechnology based herbal medicines may overcome the delivery limitation of various natural products utilizing the multi and versatile properties of various nanoparticles. This review reports the herbal anti-arthritic drugs, challenges associated with them, and pharmacodynamics/ pharmacokinetics of anti-arthritic herbal nanomedicines.
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