Plants' Natural Products as Alternative Promising Anti-candida Drugs

Pharmacognosy Reviews,2017,11,22,104-122.
Published:September 2017
Type:Review Article
Author(s) affiliations:

Sameh Soliman1,2, Dina Alnajdy1, Ali A. El‑Keblawy3, Kareem A. Mosa3,4, Ghalia Khoder5, Ayman M. Noreddin6,7

Departments of 1Medicinal Chemistry, 5Pharmaceutics and Pharmaceutical Technology, and 6Pharmacy Practice and Pharmacotherapy, College of Pharmacy, University of Sharjah, 3Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates, 2Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 4Department of Biotechnology, Faculty of Agriculture, Al‑Azhar University, Cairo, Egypt, 7Department of Pharmacy Practice, School of Pharmacy, Chapman University, Irvine, California, USA


Candida is a serious life-threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines. Several plants show significant anti-Candida activities and some of them have lower minimum inhibitory concentration, making them promising candidates for anti-Candida therapy. However, none of these plant products is marketed for anti-Candida therapy because of lack of sufficient information about their efficacy, toxicity and kinetics. This review revises major plants that have been tested for anti-Candida activities with recommendations for further use of some of these plants for more investigation and in vivo testing including the use of nanostructure lipid system.

Cite This Article

Vancouver Style ::
S. Soliman, Alnajdy, D. , El-Keblawy, A. A. , Mosa, K. A. , Khoder, G. , and Noreddin, A. M. , Plants' Natural Products as Alternative Promising Anti-candida Drugs, Pharmacognosy Reviews, vol. 11, no. 22, pp. 104-122, 2017.