Quercetin is a polyphenolic flavonoid, found naturally and widely distributed in many plants. Quercetin has a plethora of activities and due to its diverse activity profile and multifunctionality on various targets, it has become an upcoming area of interest for several researchers. Evidences suggest that researchers have put up a way forward and explored the novel approach of quercetin lipid-based formulations. Recent literature studies indicate that lipid-particulate, emulsion and vesicular systems were found to be successful in comparison to the conventional formulations.These formulations comprise of a suitable combination of natural lipids with surfactants, cosurfactants and cosolvents. Customizing lipid nanoparticles with quercetin to a particular target may also be a revolutionary method in order to optimize the therapeutic activity of drugs and mitigate toxicity. Read more. . .