Solanum nigrum Linn. (Solanaceae) commonly known as 'Black nightshade' that have been extensively used in traditional medicine in India and other parts of world to cure liver disorders, chronic skin ailments (psoriasis and ringworm), inflammatory conditions, painful periods, fevers, diarrhoea , eye diseases, hydrophobia, etc. It has been found that Solanum nigrum contains the substances, such as total alkaloid, steroid alkaloid, steroidal saponins and glycoprotein, exhibiting anti-tumor activity. In Indian traditional medicine, the plant is used as a hepatoprotective agent. In this review, we have explored the phyto-pharmacological properties of the Solanum nigrum plant and compiled its vast pharmacological applications to comprehend and synthesize the subject of its potential image of multipurpose medicinal agent.