Review Article
    Pharmacognosy Reviews
    Vol. 15
    Issue 30
    2021
    pp. 128-133
    Open Access

    Recent Updates in Research on Gymnema sylvestre

    Pallavi Shrirang Jamadagni1,Sharad D. Pawar2,Shrirang B. Jamadagni1,Manish Gautam4,Sudesh N. Gaidhani3,G.P. Prasad1,Arun M. Gurav1
    1Regional Ayurveda Research Institute, CCRAS; Min. of AYUSH, Nehru Garden, Kothrud, Pune, Maharashtra, INDIA.
    2Central Ayurveda Research Institute, CCRAS; Min. of AYUSH, 4 CN Block, Kolkata, West Bengal, INDIA.
    4Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, West Bengal, INDIA.
    3Headquarters, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Janakpuri, New Delhi, INDIA.
    Correspondence:

    *Pallavi Shrirang Jamadagni

    Regional Ayurveda Research Institute, CCRAS; Min. of AYUSH, Nehru Garden, Kothrud, Pune, Maharashtra, INDIA.

    pallavideshmukh7@gmail.com

    Copyright:

    2021 Author(s)

    Check for updates
    Published:19/10/2021
    Received: 19/05/2021
    Accepted: 24/07/2021

    Abstract

    Gymnema sylvestrae (GS) is a large woody climbing plant that is available in dry forests of India and China. It is also proven for other activities like anti-hemolytic, anti-bacterial and anti-cancer. Present review covers recent updates in research on this plant typically during last 10 years. Also, its characterization and extraction, structure activity relationship, in-vitro pharmacology, in-vivo pharmacology, pharmacodynamics, clinical pharmacology and clinical efficacy, safety and toxicity is discussed in details. Detailed review of available literature on GS indicates it is promising plant for treatment of Type 2 Diabetes Mellitus. GS acts only in presence of pancreas as it acts by stimulation of β cells of langerhans. However, it has also shown hepatotoxic property.

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    Keywords

    Gymnema sylvestre
    Diabetes
    Pharmacology
    Gymnemangenin
    Gymnemic acid
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