Opinion
    Pharmacognosy Reviews
    Vol. 20
    Issue 39
    2026
    pp. 98-101
    Open Access

    Interkingdom Three-Way Synergy Modulating Adaptation and Secondary Metabolites

    Vikrant Arya1,Ranjeet Kaur Parmar2
    1Department of Pharmaceutical Sciences, Government Pharmacy College Rakkar, Kangra, Himachal Pradesh, INDIA.
    2Department of Pharmaceutical Sciences, Government Pharmacy College Kangra at Nagrota Bagwan, Himachal Pradesh, INDIA.
    Correspondence:

    *Vikrant Arya

    Department of Pharmaceutical Sciences, Government Pharmacy College Rakkar, Kangra, Himachal Pradesh, INDIA.

    arya.vikrant30@gmail.com

    Copyright:

    2026 Author(s)

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    Published:11/03/2026
    Received: 02/11/2025
    Accepted: 12/02/2026

    Abstract

    Mutualistic complexities in nature represent an inherent part of adaptation. Interkingdom interactions among organisms helped them to survive against biotic and abiotic stress. Although mutualistic associations have been commonly observed among plants-fungi and plant-virus but the concept of tripartite association involving plants-fungus-virus has not been explored so far. The literature review depicted the presence of interactions between plants and the fungus, in which fungal endophytes/AMF aid in plant adaptation. In the case of plant-virus interactions, several viruses aid in modulating the secondary metabolites. The associated mutualistic interactions among organisms complement their survival in nature.

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    Keywords

    Mutualistic associations
    Secondary metabolites
    Symbiosis
    Three-way symbiosis
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