Effects of Mucuna pruriens (L.) Supplementation on Experimental Models of Parkinson's Disease: A Systematic Review

Pharmacognosy Reviews,2018,12,23,78-84.
Published:May 2018
Type:Review Article
Authors:
Author(s) affiliations:

Francisca Idalina Neta1, Ianara Mendonça Da Costa1, Francisca Overlânia Vieira Lima1, Luciana Cristina Borges Fernandes1, José Rodolfo Lopes De Paiva Cavalcanti1, Marco Aurélio De Moura Freire1, Eudes Euler De Souza Lucena1, Amália Cinthia Meneses Do Rêgo2, Irami Araújo Filho2, Eduardo Pereira De Azevedo2, Fausto Pierdoná Guzen1,2

1Department of Biomedical Sciences, Health Science Center, Laboratory of Experimental Neurology, State University of Rio Grande Do Norte, Mossoró, 2Department of Biomedic Sciences, School of Health, Potiguar University, Natal, Rio Grande Do Norte, Brazil

Abstract:

Introduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson's disease (PD), and has as its main component levodopa (L-DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. Materials and Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PD.