Intensification of Bioactive Compounds Extraction from Medicinal Plants using Ultrasonic Irradiation

Pharmacognosy Reviews,2014,8,16,88-95.
Published:June 2014
Type:Review Article
Author(s) affiliations:

Renata Vardanega1, Diego T. Santos1,2, M. Angela A. Meireles1

1LASEFI/DEA/FEA (School of Food Engineering), UNICAMP (University of Campinas), SP, Brazil, 2Industrial Process and Energy Systems Engineering (IPESE), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland


Extraction processes are largely used in many chemical, biotechnological and pharmaceutical industries for recovery of bioactive compounds from medicinal plants. To replace the conventional extraction techniques, new techniques as high‑pressure extraction processes that use environment friendly solvents have been developed. However, these techniques, sometimes, are associated with low extraction rate. The ultrasound can be effectively used to improve the extraction rate by the increasing the mass transfer and possible rupture of cell wall due the formation of microcavities leading to higher product yields with reduced processing time and solvent consumption. This review presents a brief survey about the mechanism and aspects that affecting the ultrasound assisted extraction focusing on the use of ultrasound irradiation for high‑pressure extraction processes intensification.