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  Indian J Med Microbiol
 

Figure 3: (a) An isobologram, used to determine whether drug combinations produce effects that differ from the effects of the drugs used individually. When the calculated ratio for two combined inhibitors fall in quadrants, A depicts synergy, B an additive effect, and C a noninteractive effect, whilst D depicts an antagonistic interaction (adapted from [164]). (b) Response of a candidate bacterial strain to a conventional antibiotic and/or a plant extract: (i) sensitive bacteria + antibiotic, or resistant bacteria + plant extract; (ii) resistant bacteria + antibiotic; (iii) extensively/totally resistant bacteria + antibiotic + plant extract; and (iv) extensively/totally resistant bacteria + antibiotic

Figure 3: (a) An isobologram, used to determine whether drug combinations produce effects that differ from the effects of the drugs used individually. When the calculated ratio for two combined inhibitors fall in quadrants, A depicts synergy, B an additive effect, and C a noninteractive effect, whilst D depicts an antagonistic interaction (adapted from [164]). (b) Response of a candidate bacterial strain to a conventional antibiotic and/or a plant extract: (i) sensitive bacteria + antibiotic, or resistant bacteria + plant extract; (ii) resistant bacteria + antibiotic; (iii) extensively/totally resistant bacteria + antibiotic + plant extract; and (iv) extensively/totally resistant bacteria + antibiotic