|Year : 2017 | Volume
| Issue : 21 | Page : 19-22
Antifertility effect of Bougainvillea spectabilis or paper flower
Anisa Ghogar1, Wannee Jiraungkoorskul2
1 Mahidol University International College, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand
2 Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand
|Date of Web Publication||11-Apr-2017|
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Bougainvillea spectabilis (Family: Nyctaginaceae), commonly referred to as Great Bougainvillea or Paper Flower, is one of the traditional medicinal plants with potential antifertility activity. The aqueous extract and decoction of this plant have been used as fertility control among the tribal people in many countries. Furthermore, it has been shown to possess anticancer, antidiabetic, antihepatotoxic, anti-inflammatory, antihyperlipidemic, antimicrobial, antioxidant, and antiulcer properties. Its phytoconstituents such as alkaloids, essential oils, flavonoids, glycosides, oxalates, phenolics, phlobotannins, quinones, saponins, tannins, and terpenoids were reported as the basis of its efficacious therapeutic properties. The other important constituents which contribute to the remedial properties are bougainvinones, pinitol, quercetagetin, quercetin, and terpinolene. Published information on the antifertility property of B. spectabilis was gathered by the use of different database platforms including Google Scholar, ScienceDirect, PubMed, SciFinder, and Scopus. These database platforms were used to provide an up-to-date review on its importance.
Keywords: Antifertility, Bougainvillea spectabilis, paper flower, phytochemical substance, plant
|How to cite this article:|
Ghogar A, Jiraungkoorskul W. Antifertility effect of Bougainvillea spectabilis or paper flower. Phcog Rev 2017;11:19-22
| Introduction|| |
In 2016, the world population is estimated at 7.4 billion; the number is expected to increase to 9.6 billion in 2050 and 11.2 billion in 2100. Fertility control is a significant issue of the global and the national public health. Several effective approaches for the induction of infertility have been investigated over a long period including hormonal, chemical, and immunological approaches., However, these approaches possess various side effects such as obesity, thromboembolism, and carcinogenic effects. Therefore, researchers are interested in natural products such as plants to be used as abortifacient and as contraceptive. An ethnobotanical survey of fertility conditions among the tribal people in many countries was reported, for example, Kamrup District, Assam in India, Tswapong North in Eastern Botswana, Ebonyi State in Nigeria, and Ibadan in Southwest Nigeria. Medicinal plants with potential of antifertility activity are bladder cherry, Physalis alkekengi; crab's eye creeper, Abrus precatorius; abuta, Cissampelos pareira; turmeric, Curcuma longa; climbing milkweed, Sarcostemma secamone; bellyache bush, and Jatropha gossypifolia. The present review is to provide an up-to-date information of the properties of Bougainvillea spectabilis, one of the plants that are being investigated for diverse health benefits.
| Plant Description|| |
B. spectabilis is sometimes referred to as “Paper Flower” because its bracts are thin and papery. The most common Bougainvillea color is purple or magenta, the others are range from white to orange. It also has two colors on the same tree, for example, pink and white or pink and orange that is called rainbow paper flower [Figure 1]. Stem is a woody perennial vine, with multitrunked and large clumping stems which spread up to 2–4 m. The clumping stem uses thinning branches attached the curved thorns. The color of growing stems is from green to dark green. The bark is pale and corky. Branching is close and short, giving rise to a very dense plant. The leaves are simple and alternate. The leaf is 5–10 cm long and 2–6 cm wide, with ovate to rounded shapes. Leaves are deep green, leathery in texture, and hairy underneath. The flowers arise in leaf axils, in clusters of three. The color of the flower is white, it is small-slender size with hairy tubes, and surrounded by showy, colorful petaloid bracts. The bracts are crinkled, fairly large, egg-shaped, and possess colors in the rose, rusty-red, magenta, and purple. The elongated five-lobed achene fruit is 1–2 cm long, has a dry, hard fruit cover.
| Taxonomical Classification|| |
The taxonomy of B. spectabilis is in the Kingdom: Plantae; Subkingdom: Viridiplantae; Infrakingdom: Streptophyta; Superdivision: Embryophyta; Division: Tracheophyta; Subdivision: Spermatophytina; Class: Magnoliopsida; Superorder: Caryophyllene; Order: Caryophyllales; Family: Nyctaginaceae; Genus: Bougainvillea; Species: B. spectabilis. Genus: Bougainvillea was first discovered in Brazil by a French navigator named Louis Antoine de Bougainvillea, in 1786., This genus has 18 species: Bougainvillea berberidifolia, Bougainvillea buttiana,Bougainvillea campanulata,Bougainvillea glabra,Bougainvillea herzogiana,Bougainvillea infesta,Bougainvillea lehmanniana,Bougainvillea lehmannii,Bougainvillea malmeana,Bougainvillea modesta,Bougainvillea pachyphylla,Bougainvillea peruviana,Bougainvillea pomacea,Bougainvillea praecox,B. spectabilis,Bougainvillea spinosa,Bougainvillea stipitata,and Bougainvillea trollii. The important species in horticulture are B. spectabilis,B. glabra, and B. peruviana.,
| Nomenclature|| |
B. spectabilis is a native plant of South America, and it is popular in South America, Asia, Africa, and other areas that spread throughout the tropical and warm climates. The vernacular name of B. spectabilis is known as Great Bougainvillea, paper flower (English); Bagan Bilash (Bengali); mao bao jin, jiu chong ge, san jiao hua, ye zi hua (Chinese); bougainvillier (French), booganbel (Hindi); buganvillea (Italian); buganvil, kembang kertas, bunga kertas (Indonesian); felila (Japanese); bougainvillea (Konkani); buganvil, buginvila, pokok bunga kertas (Malay); Cherei (Manipuri); buganvilla, veranera (Spanish); bugambilia, bogambilya (Tagalog); kagithala puvvu (Telugu); fuang fah (Thai); and hoa giay, bong giay (Vietnamese).
| Phytochemical Substances|| |
The phytochemical substances that are extracted from stem, flowers, and leaves of B. spectabilis are alkaloid, flavonoids, furanoids, glycosides, phenols, phlobotannins, quinones, saponins, steroids, tannins, and terpenoids. The other active constituents are bougainvinones peltogynoids, essential oils including methyl salicylate, terpinolene, α-(E)-ionone, pinitol, β-sitosterol, quercetin, and quercetin-3-O-rutinoside., In addition, the phytochemical constituents of B. spectabilis leaf extract revealed that tannins (27.64%), saponins (14.08%), glycosides (11.49%), flavonoids (10.05%), alkaloids (4.10%), phytate (49.27%), and oxalate (27.65%) contents are present.
| Traditional Uses|| |
From review literature regarding the traditional uses or phytochemical properties of B. spectabilis are antibacterial,,, anticancer, antidiabetic,,, antifertility,,, antifungal, anti-inflammatory,, antihyperlipidemic,, antioxidant,,, antiulcer, antiviral,, hepatoprotective, and thrombolytic activities.
| Antifertility Property of Bougainvillea Spectabilis|| |
Mishra et al. evaluated the effect of the 800 mg/kg/day of oral administration of B. spectabilis leaves on reproductive organs and fertility of male and female Swiss albino mice for 30 days. They reported that this plant can reduce the caudal epididymal sperm count from 5.05 × 106 per ml in the control group to 0.65 × 106 per ml in the treatment group (87.13%). From histology study, this plant treatment revealed the reduction in the size of seminiferous tubules along with the thickness of germinal epithelial cells and the hypertrophy of interstitial cells of Leydig. Moreover, the lumen of the tubules was found to be devoid of sperms. In female, it disrupted the estrous cycle, prolonged metestrus phase from 10.6 h in the control group to 25.0 h in the treated group. The most significant change has been due to 145.28% increase in metestrus phase along with 75.44% in estrus and 11.43% in diestrus phase. Both hormones, testosterone and estrogen levels were significantly decreased. In the same dosage Hembrom et al. evaluated the effect of 800 mg/kg/day of oral administration of B. spectabilis leaves on the fertility of male Swiss albino mice for 50 days. They reported that the anodic protein concentration was a significant increase in seminal plasma from cauda epididymis compared to the control group. This mechanism may increase more negative charges on the sperm surface membrane that might inhibit the capacitation and fertilization of the sperm. The other mechanism of this plant is to increase the M-isozymes of lactate dehydrogenase from 3.31 units/ml/h in the control group to 5.68 units/ml/h in the treatment group. The tissue is shifted from aerobic to anaerobic respiration, made pyruvate changed into lactate in the seminal plasma, and undesirably disturbs the sperm activity in the epididymis. Moreover, Ikpeme et al. studied the effect of 65 days consumed of various concentrations (150, 300, 450, and 600 mg/kg/day) of B. spectabilis leaves on reproductive organs and fertility of male rats. They reported the significant reduction in the sperm count (9.38 × 106 per ml in control group to 6.76 × 106 per ml in treatment group), viability (86.55% in control group to 63.91% in treatment group), and motility (65.75% in control group to 42.75% in treatment group). They also reported the highest dose group (600 mg/kg/day) showed the highest abnormalities of sperm (8.75%) compare to that of control (2.75%), and the testes weight was significantly reduced from 1.38 g in control to 1.10 g. From literature reviews, they were revealed that the antifertility property of this plant was from the various phytochemical substances such as saponins  and alkaloids. The antifertility property of this plant was not only reported in research studies but also in the several review articles.,,,,,
| Conclusion|| |
The antifertility property of B. spectabilis has inhibited the spermatogenic pathways that lead to decrease the number, motility, and viability of sperm. It also affects female by disrupting the estrous cycle. This plant also decreases both the sex hormones: testosterone and estrogen. This review article has attempted to compile the new medicinal plant B. spectabilis, to be one of the choices in the fertility regulation.
Special thanks to the members of the Fish Research Unit, Department of Pathobiology, Faculty of Science, Mahidol University, for their support. The author would like to thank anonymous reviewers and editors of this review article for their perceptive comments and positive criticism in this review article.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
United Nations 2015. World Population Prospects: The 2015 Revision, Key Findings and Advance Tables. Working Paper No. ESA/P/WP. 241. Department of Economic and Social Affairs, Population Division, United Nations; 2015.
Devi P, Kumar P, Nihi Dhamija I. Antifertility activity of medicinal plants on male and female reproduction. Int J Pharm Sci Res 2015;6:988-1001.
Campbell M, Sahin-Hodoglugil NN, Potts M. Barriers to fertility regulation: A review of the literature. Stud Fam Plann 2006;37:87-98.
Gill-Sharma MK. Prolactin and male fertility: The long and short feedback regulation. Int J Endocrinol 2009;2009:687259.
Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci 2010;3:62-7.
] [Full text]
Somigliana E, Peccatori FA, Filippi F, Martinelli F, Raspagliesi F, Martinelli I. Risk of thrombosis in women with malignancies undergoing ovarian stimulation for fertility preservation. Hum Reprod Update 2014;20:944-51.
Kort JD, Eisenberg ML, Millheiser LS, Westphal LM. Fertility issues in cancer survivorship. CA Cancer J Clin 2014;64:118-34.
Deka J, Kalita JC. Ethnobotanicaly important medicinal plants of Kamrup district, Assam, India, used in fertility treatment. Int Res J Pharm 2013;4:229-32.
Motlhanka DM, Nthoiwa GP. Ethnobotanical survey of medicinal plants of Tswapong North, in Eastern Botswana: A case of plants from Mosweu and Seolwane villages. Eur J Med Plants 2013;3:10-24.
Nduche MU, Omosum G, Okwulehie IC. Ethnobotanical survey of plants used as remedy for fertility conditions in Ebonyi State of Nigeria. Sch Acad J Biosci 2015;3:214-21.
Fasola TR. An ethnobotanical survey of plants used in the management and treatment of female reproductive health problems in Ibadan, Southwestern Nigeria. J Biol Agric Health 2015;5:7-11.
Montaserti A, Pourheydar M, Khazaei M, Ghorbani R. Anti-fertility effects of Physalis alkekengi
alcoholic extract in female rat. Iran J Reprod Med 2007;5:13-6.
Jahan S, Rasool S, Khan MA, Ahmad M, Zafar M, Arsahd M, et al
. Antifertility effects of ethanolic seed extract of Abrus precatorius
L. on sperm production and DNA integrity in adult male mice. J Med Plants Res 2009;3:809-14.
Jhuma S, Bhattacharya S. Cissampelos pareira
: A promising antifertility agent. Int J Res Ayurveda Pharm 2011;2:439-42.
Ghosh AK, Das AK, Patra KK. Studies on antifertility effect of rhizome of Curcuma longa
Linn. Asian J Pharm Life Sci 2011;1:349-53.
Thanga KK, Sakthidevi G, Muthukumaraswamy S, Mohan VR. Anti-fertility activity of whole plant extract of Sarcostemma secamone
(L) Bennet on male albino rats. Int Res J Pharm 2012;3:139-44.
Jain S, Choudhary GP, Jain DK. Pharmacological evaluation and antifertility activity of Jatropha gossypifolia
in rats. Biomed Res Int 2013;2013:125980.
Warren W. Handy Pocket Guide to Tropical Flowers. Singapore: Tuttle Publishing; 2013. p. 64.
Kobayashi KD, McConnell J, Griffis J. Bougainvillea
. Ornamentals and Flowers. OF-38, Cooperative Extension Service, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa; 2007.
Integrated Taxonomic Information System (ITIS). Bougainvillea spectabilis
Willd. Taxonomic Serial No.:895413. Geological Survey, VA, USA; 2016.
Fawad SA, Khalid N, Asghar W, Suleria HA.In vitro
comparative study of Bougainvillea spectabilis “stand”
leaves and Bougainvillea variegate
leaves in terms of phytochemicals and antimicrobial activity. Chin J Nat Med 2012;10:441-7.
The Plant List. Bougainvillea
. The Plant List: A Working List of All Plant Species. Ver. 1; 2010.
Saikia H, Lama A. Effect of Bougainvillea spectabilis
leaves on serum lipids in albino rats fed with high fat diet. Int J Pharm Sci Drug Res 2011;3:141-5.
Mahajan MM, Dudhgaonkar S, Deshmukh SN. Anti-diabetic and hypolipidemic effects of the aqueous leaf extract of Bougainvillea
species. Int J Basic Clin Pharmacol 2015;4:596-7.
Rashid F, Sharif N, Ali I, Sharif S, Nisa FU, Naz S. Phytochemical analysis and inhibitory activity of ornamental plant (Bougainvillea spectabilis
). Asian J Plant Sci Res 2013;3:1-5.
Do LT, Aree T, Siripong P, Pham TN, Nguyen PK, Tip-Pyang S. Bougainvinones A-H, peltogynoids from the stem bark of purple Bougainvillea spectabilis
and their cytotoxic activity. J Nat Prod 2016;79:939-45.
Vukovic N, Kacaniova M, Hleba L, Sukdolak S. Chemical composition of the essential oil of Bougainvillea spectabilis
from Montenegro. J Essential Oil Bearing Plants 2013;16:212-5.
Narayanan CR, Joshi DD, Mujumdar AM, Dhekne VV. Pinitol – A new antidiabetic compound from the leaves of Bougainvillea spectabilis
. Curr Sci 1987;56:139-41.
Jawla S, Kumar Y, Khan MS. Isolation of phytoconstituents and antihyperglycemic activity of Bougainvillea spectabilis
root bark extracts. Lat Am J Pharm 2013;32:1389-95.
Ikpeme EV, Ekaluo UB, Udensi OU, Ekerette EE, Pius M. Phytochemistry and reproductive activities of male albino rats treated with crude leaf extract of great Bougainvillea
). Asian J Sci Res 2015;8:367-73.
Umamaheswari A, Shreevidya R, Nuni A.In vitro
antibacterial activity of Bougainvillea spectabilis
leaves extracts. Adv Biol Res 2008;2:1-5.
Kumara Swamy M, Sudipta KM, Lokesh P, Neeki MA, Rashmi W, Bhaumik SH, et al
. Phytochemical screening and in vitro
antimicrobial activity of Bougainvillea spectabilis
flower extracts. Int J Phytomed 2012;4:375-9.
Hajare CN, Inamdar FR, Patil RV, Shete CS, Wadkar SS, Patil KS, et al
. Antibacterial activity of the leaves of Bougainvillea spectabilis
against E. coli
NCIM 2832 and M. aureus
NCIM 5021. Int J Pharm Sci Rev Res 2015;34:194-6.
Kumar DJ, Sonia K, Madhan R, Selvakumar K. Antiyeast, antioxidant and anticancer activity of Tribulus terrestris
Linn and Bougainvillea spectabilis
Linn. Res J Pharm Technol 2011;4:1483-9.
Narayanan CR, Joshi DD, Mujumdar AM. Hypoglycemic action of Bougainvillea spectabilis
leaves. Curr Sci 1984;53:579-81.
Saikia H, Das S. Antidiabetic action of Bougainvillea spectabilis
(leaves) in normal and alloxan induced diabetic albino rats. Indian Drugs 2009;46:391-7.
Jawla S, Kumar Y, Khan MS. Hypoglycemia activity of Bougainvillea spectabilis
stem bark in normal and alloxan-induced diabetic rats. Asian Pac J Trop Biomed 2012;2:919-23.
Mishra N, Joshi S, Tandon VL, Munjal A. Evaluation of antifertility potential of aqueous extract of Bougainvillea spectabilis
leaves in swiss albino mice. Int J Pharm Sci Drug Res 2009;1:19-23.
Hembrom AR, Pragya S, Kumar J, Singh VN. Effects of aqueous leaf extract of Bougainvillea spectabilis
on seminal quality of mice. J Adv Zool 2011;32:119-22.
Hembrom AR, Pragya S, Singh VN. Selective and directional influence of Bougainvillea spectabilis
on anodic electrophoretic proteins and m-isozymes of LDH in semen of mice in relation to fertility control. Int Res J Pharm 2014;5:576-7.
Ali MS, Ibrahim SA, Ahmed F, Pervez MK. Colour versus bioactivity in the flowers of Bougainvillea spectabilis
). Nat Prod Res 2005;19:1-5.
Joshi DD, Mujumdar AM, Narayanan CR. Antiinflammatory activity of Bougainvillea spectabilis
leaves. Indian J Pharm Sci 1984;46:187-8.
Mandal G, Chatterjee C, Chatterjee M. Evaluation of anti-inflammatory activity of methanolic extract of leaves of Bougainvillea spectabilis
in experimental animal models. Pharmacogn Res 2015;7:18-22.
Adebayo JO, Adesokan AA, Olatunji LA, Buoro DO, Aoladoye AO. Effect of ethanolic extract of Bougainvillea spectabilis
leaves on haematological and serum lipid variables in rats. Biochemistry 2005;17:45-50.
Chaires-Martinez L, Monroy-Reyes E, Bautista-Bringas A, Jimenez-Avalos HA, Sepulveda-Jimenez G. Determination of radical scavenging activity of hydroalcoholic and aqueous extracts from Bauhinia divaricata
and Bougainvillea spectabilis
using the DPPH assay. Pharmacognosy Res 2009;1:238-44.
Venkatachalam RN, Singh K, Marar T. Bougainvillea spectabilis
, a good source of antioxidant phytochemicals. Res J Pharm Biol Chem Sci 2012;3:605-13.
Dhankhar S, Sharma M, Ruhil S, Balhara M, Kumar M, Chhillar AK. Evaluation of antimicrobial and antioxidant activities of Bougainvillea spectabilis.
Int J Pharm Pharm Sci 2013;5:178-82.
Malairajan P, Gopalakrishnan G, Narasimhan S, Jessi KV. Antiulcer activity of crude alcoholic extracts of Bougainvillea spectabilis
Willd. Jundishapar J Nat Pharm Prod 2007;2:1-6.
Bolognesi A, Polito L, Olivieri F, Valbonesi P, Barbieri L, Battelli MG, et al.
New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities from Basella rubra
L. and Bougainvillea spectabilis
Willd. Planta 1997;203:422-9.
Balasaraswathi R, Sadasivam S, Ward M, Walker JM. An antiviral protein from Bougainvillea spectabilis
roots; Purification and characterization. Phytochemistry 1998;47:1561-5.
Malomo SO, Adebayo JO, Arise RO, Olorunniji FJ, Egwim EC. Effects of ethanolic extract of Bougainvillea spectabilis
leaves on some liver and kidney function indices in rats. Phytochem Pharmacol 2006;17:261-72.
Sherwani SK, Khan MM, Zubair A, Shh MA, Kazmi SU. Evaluation of in vitro
thrombolytic activity of Bougainvillea spectabilis
leaf extract. Int J Pharm Sci Rev Res 2013;21:6-9.
Francis G, Kerem Z, Makkar HP, Becker K. The biological action of saponins in animal systems: A review. Br J Nutr 2002;88:587-605.
Kumar CP, Sachin J. Pharmacological action of plant alkaloids in female reproductive system of test animals and/or human beings: A review. Int J Pharm Sci Rev Res 2013;23:98-107.
Joshi SC, Sharma A, Chaturvedi M. Antifertility potential of some medicinal plants in males: An overview. Int J Pharm Pharm Sci 2011;3:204-17.
Sharma RK, Goyal AK, Bhat RA. Antifertility activity of plants extracts on female reproduction: A review. Int J Pharm Biol Sci 2013;3:493-514.
Singh G, Mali PC. A review on antifertility effects of Indian plants used traditional for contraception. Int J Pharm Bio Sci 2015;6:209-17.
Dutta S. A review of plants used as contraceptives. Int J Innov Pharm Sci Res 2015;3:655-62.
Meerwal P, Jain GC. Male fertility regulation with plant products: A review. Int J Pharm Chem Biol Sci 2015;5:146-62.
Azamthulla M, Balasubramanian R, Kavimani S. A review on medicinal plants exhibiting antifertility activity. World J Pharm Pharm Sci 2015;4:243-72.