|Year : 2016 | Volume
| Issue : 20 | Page : 84-89
Overviews of biological importance of quercetin: A bioactive flavonoid
Alexander Victor Anand David1, Radhakrishnan Arulmoli1, Subramani Parasuraman2
1 Unit of Anatomy, Faculty of Medicine, AIMST University, Bedong, Malaysia
2 Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Bedong 08100, Malaysia
|Date of Web Publication||14-Nov-2016|
Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Bedong 08100
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
Keywords: Antioxidant, bioflavonoid, free radical, quercetin
|How to cite this article:|
Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: A bioactive flavonoid. Phcog Rev 2016;10:84-9
|How to cite this URL:|
Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: A bioactive flavonoid. Phcog Rev [serial online] 2016 [cited 2017 May 26];10:84-9. Available from: http://www.phcogrev.com/text.asp?2016/10/20/84/194044
| Introduction|| |
Plants and plant parts are used for its scent, flavor, or therapeutic properties. There are a number of advantages associated with using plants and plant phytoconstituents as opposed to pharmaceutical products. The plants extracts and its phytoconstituents are proven for its biological activities such as antidiabetic, antihyperlipidemic, free-radical scavenging, and anti-inflammatory activities. Most of the time, free-radical are playing an important role in the development of metabolic disorders, and it affects the quality of life. Nature is a balanced system providing a balanced environment to have a good and healthy life. The search leading to compound with antioxidant activity has increased in the last few decades. The plant such as Curcuma domestica valeton, Cuscuta reflexa, Daucus carota, Emblica officinalis, Foeniculum vulgare, Glycyrrhiza glabra, Mangifera indica, Momordica charantia, Ocimum sanctum, Psoralea corylifolia, Santalum album, Solanum nigrum, Swertia chirayita, and Withania somnifera are known for its antioxidant activity and these plants showed significant biological activities against disease such as diabetes, hypercholesterolemia, and inflammatory disorders.,
Quercetin is one of the important bioflavonoids present in more than twenty plants material [Table 1] and which is known for its anti-inflammatory, antihypertensive, vasodilator effects, antiobesity, antihypercholesterolemic and antiatherosclerotic activities., Free-radical are one of the key factors for the development of the diseases such as hypertension, vascular disorders, and metabolic syndrome. Disease caused by free-radical and oxidant is summarized in [Table 2]. The objective of this review is to compile the biological and pharmacological importance of quercetin, a bioactive flavonoid.
Free-Radical And Health
The production of physiological amount (low or moderate concentrations) of free-radical is essential to fight against an unfavorable environment. Indeed, phagocytes release free radicals to destroy pathogenic microbes. The free radicals such as nitric oxide (NO), superoxide anion, and related reactive oxygen species (ROS) play an important role as regulatory mediators in signaling processes. In higher organisms, NO and ROS regulate vascular tone, oxygen tension in control of ventilation, and erythropoietin production. Free radicals can be produced from enzymatic and nonenzymatic reactions. The respiratory chain, phagocytosis, prostaglandin synthesis, and the cytochrome P450 system are involved in enzymatic reactions generating free radicals and oxygen initiates the nonenzymatic reactions. ROS and reactive nitrogen species are generated from either endogenous such as immune cell activation, inflammation, mental stress, excessive exercise, ischemia, infection, cancer, aging, or exogenous sources such as air pollution, water pollution, cigarette smoke, alcohol, heavy metals, transition metals, pharmaceutical substances/pharmacological agents, and radiation., Excess production of free-radical alters the cellular functions and induces chronic and degenerative diseases.
Antioxidants inhibit the oxidation reaction of other molecules that can produce free radicals. These antioxidants are natural or synthetic supplement which helps to improve the free radicals induced pathological conditions. Vitamin A, Vitamin C, and Vitamin E are dietary antioxidants, commonly present in vegetables and fruits which help to inhibit the free radicals. Many plant flavonoids have rich antioxidant properties which are used for the treatment of inflammatory disorders.
Flavonoids As Antioxidant
flavonoids (the term is derived from the Latin word “flavus,” meaning yellow) are phenolic substances which exhibit biological activities including antiallergenic, antiviral, anti-inflammatory, and vasodilating actions. Flavonoids are mostly found in fruits, vegetables, and certain beverages that have versatile beneficial antioxidant effects. Approximately, more than 3000 varieties of flavonoids have been identified, and it has aroused particular interest recently because of their potential beneficial effect on human health reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor, antioxidant, and treatment of neurodegenerative disorders. Flavonoids are categorized into six classes according to the chemical structure into flavonols, flavones, flavanones, flavanols, isoflavones, and anthocyanidins.
Flavonoids can prevent injury caused by free radicals by scavenging of ROS, activation of antioxidant enzymes, metal chelating activity, reduction of α-tocopheryl radicals, inhibition of oxidases, and mitigation of oxidative stress caused by NO, increase in uric acid levels and increase in antioxidant properties of low-molecular antioxidants. Flavonoids are also act as prooxidants and promoting the oxidation of other compounds.
The name quercetin (3,3',4', 5, 7-pentahydroxyflavone) [Figure 1] comes from the Latin word “Quercetum” which means Oak Forest, belongs to the class called flavonols that cannot be produced in the human body. It is yellow color and is poorly soluble in hot water, quite soluble in alcohol and lipids and is insoluble in cold water. Quercetin is said to be one of the most widely used bioflavonoids for the treatment of metabolic and inflammatory disorders.
It is one of the most abundant dietary flavonoids found in fruits (mainly citrus), green leafy vegetables as well as many seeds, buckwheat, nuts, flowers, barks, broccoli, olive oil, apples, onions, green tea, red grapes, red wine, dark cherries, and berries such as blueberries and cranberries. The highest concentrations of flavonols were found in vegetables such as onions and broccoli, fruits such as apples, cherries, and berries, and drinks such as tea and red wine.
Antioxidant Properties Of Quercetin
Quercetin, a plant-derived aglycone form of flavonoid glycosides, has been used as a nutritional supplement and may be beneficial against a variety of diseases. Some of the beneficial effects include cardiovascular protection, anticancer, antitumor, anti-ulcer, anti-allergy, anti-viral, anti-inflammatory activity, anti-diabetic, gastroprotective effects, antihypertensive, immunomodulatory, and anti-infective.
Quercetin can also protect against environmental causes of free radicals such as smoking. Cigarette tar is a source of free radicals which has been found to damage erythrocyte membranes. It was also found that quercetin and its conjugate metabolites could protect erythrocytes from the membranous damage that is caused by smoking.
Pharmacological Importance Of Quercetin
When parts of our human body exposed to harmful or irritating stimuli, there is a biological response called inflammation which plays a role in self-protection; the aim is to remove damaged cells, pathogens, or any harmful stimuli and begins the healing process. Inflammation does not necessarily mean infection. In most cases, infection is caused by a virus, bacteria, or fungus while inflammation process is the body's response trying to heal itself. One of the core most remarkable properties of quercetin is its ability to modulate inflammation. Quercetin inhibits inflammatory enzymes cyclooxygenase (COX) and lipooxygenase thereby decreasing inflammatory mediators such as prostaglandins and leukotrienes.,
Nutrition scientists from Michigan State University explored the impact of dietary flavonoids such as quercetin in their general roles as systemic anti-inflammatory agents. Elevated C-reactive protein (CRP) levels are associated with numerous disease states such as obesity, heart disease, and lupus. It has been identified through this study that intake of certain foods can lower the levels of the inflammatory risk factor (CRP). In preclinical in vitro studies, quercetin showed a significant reduction in the levels of inflammatory mediators such as NO synthase, COX-2, and CRP in human hepatocyte-derived cell line. In rats, quercetin (80 mg equivalent dose) inhibited both acute and chronic inflammation and also showed significant antiarthritic activity against adjuvant-induced arthritis.,
Askari et al. studied the effect of 2-month flavonoid quercetin (500 mg) supplementation in healthy male nonprofessional athletes with regular exercise, and the study results showed a significant decrease in the levels of CRP. However, in a pathological condition, quercetin did not show any significant alteration in the levels of CRP in women with rheumatoid arthritis (RA). The study was conducted for 8 weeks, and the RA patients were administered with quercetin 500 mg/day. In addition to that, quercetin having the ability to inhibit xanthine oxidase prevents the accumulation of uric acid, which may helpful the subjects who are suffering from gout.
Cardiovascular disease prevention
Cardiovascular diseases have become a ubiquitous cause of morbidity and a leading contributor to mortality in most countries. It has been identified that diet plays a major in the etiology of cardiovascular disease. Reported meta-analyses studies showed an inverse association between fruit and vegetable consumption and the occurrence of Stroke. Regular intake of fruit and vegetable consumption decreases the risk of stroke and coronary heart disease.,
Plants are the richest source for bioflavonoids, minerals, vitamin, and many more which exhibits activity against metabolic and inflammatory disorders. Many flavonoids exert antihypertensive, anti-atherosclerotic, antiplatelet activity, and positive effects against endothelial dysfunction. Flavonoids existing over many years such as quercetin possess a wide spectrum of biological activities which may have a positive influence on cardiovascular diseases. In a study done by Greek cardiologists on thirty men who already had coronary heart disease (CHD) on the consumption of red grape polyphenol extract rich in quercetin caused an increase in flow-mediated dilation of major arteries, a potent indicator of improved endothelial health.
Quercetin inhibits the platelet aggregation and improves the health of the endothelium. In addition to that, it also protects against CHD and reduces the risk of mortality caused by low-density lipoprotein (LDL). It is known to exhibit important vasorelaxant properties on isolated arteries which helps to lower blood pressure and prevents the development of cardiac hypertrophy. Quercetin prevents damage to LDL cholesterol and studies revealed that people who consume high in flavonoid containing food supplements have lower cholesterol. In one of the study, it was found that people who consume quercetin and an alcohol-free red wine extract (which contains quercetin) inhibit LDL oxidation. Quercetin at 150 mg/day reduces systolic blood pressure and plasma oxidized LDL levels in overweight subjects who were at high risk of heart disease in the 6-week clinical trial.
Quercetin has a specific feature which inhibits fat accumulation in maturing human fat cells and simultaneously triggers apoptosis (programmed destruction) in existing fat cells., In addition, quercetin also blocks the uptake of glucose from the blood, blocks the fat cell production, and enhances fat cell necrosis., The dietary fiber intakes from cereals or from fruit were, independent of each other, inversely associated with the risk of CHD mortality. Ten grams of dietary fiber intake from cereals lowered CHD mortality risk by 29% and that of dietary fiber from fruit lowered CHD mortality risk by 35%.,
Neurodegenerative diseases such as Alzheimer's and Parkinson's disease as well as neuronal injury associated with stroke are associated with neuroinflammatory processes in the central nervous system. There has been intense interest recently in the potential of flavonoids to modulate neuronal function and prevent against age-related neurodegeneration.
Flavonoids exert multiple beneficial effects on the vascular system leading to changes in cerebrovascular blood flow which are capable of changing neuronal morphology causing neurogenesis and angiogenesis. In addition to that, it also has the potential to protect neurons against injury induced by neurotoxins. The consumption of flavonoids rich food limits neurodegeneration and to reverse age-dependent loss in cognitive performance.
Quercetin along with with ascorbic acid reduces the incidence of oxidative damage to human lymphocytes and neurovascular structures in the skin and inhibits damage to neurons. It is known to protect brain cells against the oxidative stress, which damages tissue leading to Alzheimer and other neurological conditions. Flavonoids believed to play a crucial role to protect neuronal injury. Flavonoid exerts neuroprotective actions within the brain including a potential to protect neurons against injury induced by neurotoxins. It also has additional ability to suppress neuroinflammation and promotes memory, learning, and cognitive functions. Flavonoids are also found to exhibit protective features capable of preventing more serious degenerative diseases and many forms of cerebrovascular disease associated with dementia and stroke effecting predominantly elderly people. Flavonoid-rich plant or food supplement improves the cognition functions and protects vulnerable neurons by enhancing existing neuronal function or by stimulating neuronal regeneration.
Cancer and apoptosis
Epidemiological survey showed diet with more vegetables and fruits have protective effect against cancer. Quercetin has potential anticancer properties which include antiproliferative, growth factor suppression, and antioxidant.
Quercetin has potent anticarcinogenic properties and known to contribute as apoptosis inductor whereby it decreases the growth of tumor in and brain, liver, colon, and other tissues and inhibits the spread of malignant cells., Cruz-Correa et al. studied the combination treatment with curcumin and quercetin on familial adenomatous polyposis (FAP) patients. The patients were administered with curcumin 480 mg and quercetin 20 mg orally 3 times a day for mean of 6 months. At the end of the study, curcumin and quercetin reduced the number and size of ileal and rectal adenomas with minimal adverse effects.
Quercetin inhibits hexavalent chromium (Cr[VI]), a chemical carcinogen-induced cell transformation such as cell visibility loss, ROS generation and MicroRNA-21 (miR-21) elevation in human colon cancer Caco-2-cells., Both in vitro and in vivo cancer studies, quercetin was said to have a beneficial effect against prostate cancer.
Ulcer and gastritis
The studies have shown that quercetin inhibits gastric acid secretion and lipid peroxidation of gastric cells thereby serves as gastroprotective agents. It also inhibits Helicobacter pylori infection. Suzuki et al. studied the antioxidant and antiulcer effect of quercetin 50 and 100 mg/kg against ethanol-induced gastric mucosal injury model in rats and results suggest that quercetin has favorable anti-ulcer activity. The anti-ulcer activity of quercetin due to its free-radical scavenging properties or its increased gastric mucus production.,
Antibacterial and antiviral activity
Quercetin is known to exhibit antibacterial effects against almost all strains of bacteria, particularly affecting gastrointestinal, respiratory, urinary, and dermal system. Their anti-infective and antireplicative ability possibly contributes to the antiviral characteristics. Viruses which commonly respond to flavonoids are adenovirus, herpes simplex virus, Japanese encephalitis virus, and respiratory syncytial virus.,,
Allergies, asthma, hay fever, and hives
Quercetin exerts anti-allergy effects by inhibiting the release of histamine from mast cells and other allergic substance thus acting as a natural antihistamine. Quercetin's ability to prevent allergic effects has tremendous implications for the treatment and prevention of asthma and bronchitis. The cell membranes of mast cells which have been known to be an immune gateway to the brain as well as the environment and emotional stress.
Ferry et al. studied the pharmacokinetic properties of intravenous injection of quercetin on cancer patients at the dose levels of 60–2000 mg/m 2. From the study, the determined quercetin safety dose is 945 mg/m 2. In toxic dose, quercetin caused emesis, hypertension, nephrotoxicity, and reduction in serum potassium. The distribution and elimination half-life of intravenous quercetin is 0.7–7.8 min, and 3.8–86 min, respectively. The clearance is 0.23–0.84 L/min/m 2, and volume of distribution is 3.7 L/m 2. Erlund et al. studied the pharmacokinetic properties of 8, 20, and 500 mg quercetin aglycone orally in healthy volunteers. Graefe et al. also studied pharmacokinetic properties of quercetin at the dose levels of 200 mg. Cmax and Tmax of quercetin are 2.3 ± 1.5 µg/mL and 0.7 ± 0.3 h, respectively.
Clinical Effect Of Quercetin
The ability of quercetin is claimed to exert many beneficial effects on health, including protection against various diseases such as osteoporosis, lung cancer, and cardiovascular disease. The studies showed that there has been a reduction in the risk of cardiovascular disease in subjects, who had a high intake of flavonoids. Progressive disorder of the lung parenchyma and airways or also known as chronic obstructive pulmonary disease (COPD) which happens to be the third-leading cause of death in the USA. Therapies thus far for COPD, unfortunately, is said to be partially effective with possibilities of side effects. Increasing evidence indicates that quercetin supplementation may be beneficial in its treating this condition. In the previous preclinical study, it has been demonstrated a 4-fold increase in plasma quercetin levels significantly decreased lung inflammation and prevented disease progression. The effects of quercetin and its derivatives against inflammation, in vivo models, suggest that it is a potent anti-inflammatory agent. In in vivo study in mice has been reported to show a reduction in the expression of inflammatory genes using a quercetin-enriched diet. In a 12 weeks clinical trial, quercetin (1000 mg/day) reduced the upper respiratory tract infection rates in middle and older age subjects.
Quercetin has been reported to have features of neuroprotection in rat brain when used in combination with fish oil. Subsequently, it has also been reported to show beneficial effects against neurodegenerative diseases., Quercetin with its radical scavenging potential is said to be capable of preventing cancer which is induced by oxidative stress.
Quercetin supplementation (150 mg/day) reduced systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects in 5 weeks double-blind trial. In another study, quercetin does not affect the fasting serum concentration of total cholesterol and reduced the levels of high-density lipoprotein cholesterol and apoA1 in apoε4 carrier and reduced blood pressure in obese carriers of the apo ε3/ε3 genotype. Brüll et al. studied the effect of quercetin 162 mg/day on overweight-to-obese patients with prehypertension and Stage I hypertension and concluded that quercetin supplementation lower ambulatory blood pressure in patients with hypertension. Quercetin 500 mg/day also reduced systolic blood pressure in women with Type 2 diabetes. Cruz-Correa et al. studied the effect of quercetin (20 mg) and curcumin (480 mg) on FAP in five patients and found to be effective against FAP. Combination of quercetin (20 mg) and curcumin (480 mg) showed benefaction effect in patient who dependent cadaveric kidney recipients.
In another clinical trial, quercetin 250 mg (twice daily for 4 weeks; per oral) did not show any significant effect on oral lichen planus.
| Conclusion|| |
Quercetin is a flavonoid with antioxidant properties. The ability of quercetin is claimed to exert many beneficial effects on health, including protection against various diseases such as osteoporosis, lung cancer, and cardiovascular disease. The studies showed that there has been a reduction in the risk of cardiovascular disease in subjects, who had a high intake of flavonoids. Flavonols is the most prominent flavonoids in fruits and vegetables and of these, quercetin is the most commonly consumed in the human diet.
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| References|| |
Gupta M, Mazumder UK, Gomathi P, Selvan VT. Antiinflammatory evaluation of leaves of Plumeria acuminata
. BMC Complement Altern Med 2006;6:36.
Nigam V, Sodhi JS. Some medicinal plants with antioxidant activity – A review. Int J Pharm Biol Sci 2014;4:173-8.
Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Radiance 2006;5:326-34.
Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids. Biomed Res Int 2014;2014:480258.
Sultana B, Anwar F. Flavonols (Kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chem 2008;108:879-84.
Parasuraman S, Maithili KS. Antioxidant and drug metabolism. Free Radic Antioxid 2014;4:1-2.
Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4:89-96.
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
Blokhina O, Virolainen E, Fagerstedt KV. Antioxidants, oxidative damage and oxygen deprivation stress: A review. Ann Bot 2003;91:179-94.
Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Int Pharm Sci 2011;1:25-41.
Agrawal AD. Pharmacological activities of flavonoids: Review. Int J Pharm Nanotechnol 2011;4:1394-7.
Pal DK, Verma P. Flavonoids: A powerful and abundant source of antioxidants. Int J Pharm Pharm Sci 2013;5:95-8.
Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 2011;82:513-23.
Lakhanpal P, Rai DK. Quercetin: A versatile flavonoid. Int J Med Update 2007;2:22-37.
Begum AN, Terao J. Protective effect of quercetin against cigarette tar extract-induced impairment of erythrocyte deformability. J Nutr Biochem 2002;13:265-72.
Xiao X, Shi D, Liu L, Wang J, Xie X, Kang T, et al
. Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling. PLoS One 2011;6(8):e22934.
Warren CA, Paulhill KJ, Davidson LA, Lupton JR, Taddeo SS, Hong MY, et al.
Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J Nutr 2009;139:101-5.
Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr 2008;138:753-60.
García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, et al
. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 2007;557:221-9.
Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001;56:683-7.
Mamani-Matsuda M, Kauss T, Al-Kharrat A, Rambert J, Fawaz F, Thiolat D, et al.
Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol 2006;72:1304-10.
Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci 2012;17:637-41.
Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, et al.
The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med 2014;5:293-301.
Ahmad NS, Farman M, Najmi MH, Mian KB, Hasan A. Pharmacological basis for use of Pistacia integerrima
leaves in hyperuricemia and gout. J Ethnopharmacol 2008;117:478-82.
Parasuraman S, Kumar E, Kumar A, Emerson S. Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models. J Pharmacol Pharmacother 2010;1:38-41.
Dauchet L, Amouyel P, Dallongeville J. Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies. Neurology 2005;65:1193-7.
He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: Meta-analysis of cohort studies. Lancet 2006;367:320-6.
Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, et al.
Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 2005;12:596-600.
Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007;137:2405-11.
Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI, Howard AN. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem 2000;46 (8 Pt 1):1162-70.
Egert S, Bosy-Westphal A, Seiberl J, Kürbitz C, Settler U, Plachta-Danielzik S, et al.
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr 2009;102:1065-74.
Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 2008;373:545-9.
Park HJ, Yang JY, Ambati S, Della-Fera MA, Hausman DB, Rayalam S, et al.
Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food 2008;11:773-83.
Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 2005;386(Pt 3):471-8.
Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, et al.
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci 2008;82:1032-9.
Pereira MA, O'Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, et al.
Dietary fiber and risk of coronary heart disease: A pooled analysis of cohort studies. Arch Intern Med 2004;164:370-6.
Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies. Eur J Clin Nutr 2003;57:904-8.
Choi GN, Kim JH, Kwak JH, Jeong CH, Jeong HR, Lee U, et al
. Effect of quercetin on learning and memory performance in ICR mice under neurotoxic trimethyltin exposure. Food Chem 2012;132:1019-24.
Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP. The neuroprotective potential of flavonoids: A multiplicity of effects. Genes Nutr 2008;3:115-26.
Youdim KA, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: A multiplicity of effects. Free Radic Biol Med 2001;30:583-94.
Lamson DW, Brignall MS. Antioxidants and cancer, part 3: Quercetin. Altern Med Rev 2000;5:196-208.
Akan Z, Garip AI. Antioxidants may protect cancer cells from apoptosis signals and enhance cell viability. Asian Pac J Cancer Prev 2013;14:4611-4.
Vásquez-Garzón VR, Arellanes-Robledo J, García-Román R, Aparicio-Rautista DI, Villa-Treviño S. Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic Res 2009;43:128-37.
Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, et al.
Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2006;4:1035-8.
Pratheeshkumar P, Son YO, Divya SP, Wang L, Turcios L, Roy RV, et al
. Quercetin inhibits Cr (VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget 2016;[Ahead of print].
Han M, Song Y, Zhang X. Quercetin suppresses the migration and invasion in human colon cancer caco-2 cells through regulating toll-like receptor 4/nuclear factor-kappa B pathway. Pharmacogn Mag 2016;12 Suppl 2:S237-44.
Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review). Oncol Rep 2015;33:2659-68.
Suzuki Y, Ishihara M, Segami T, Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol 1998;78:435-41.
Alarcón de la Lastra C, Martín MJ, Motilva V. Antiulcer and gastroprotective effects of quercetin: A gross and histologic study. Pharmacology 1994;48:56-62.
Johari J, Kianmehr A, Mustafa MR, Abubakar S, Zandi K. Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus. Int J Mol Sci 2012;13:16785-95.
Cushnie TP, Lamb AJ. Antimicrobial activity of flavonoids. Int J Antimicrob Agents 2005;26:343-56.
Ramos FA, Takaishi Y, Shirotori M, Kawaguchi Y, Tsuchiya K, Shibata H, et al.
Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa
) skin. J Agric Food Chem 2006;54:3551-7.
Ferry DR, Smith A, Malkhandi J, Fyfe DW, deTakats PG, Anderson D, et al.
Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo
tyrosine kinase inhibition. Clin Cancer Res 1996;2:659-68.
Erlund I, Kosonen T, Alfthan G, Mäenpää J, Perttunen K, Kenraali J, et al.
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000;56:545-53.
Graefe EU, Wittig J, Mueller S, Riethling AK, Uehleke B, Drewelow B, et al.
Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol 2001;41:492-9.
Heinz SA, Henson DA, Austin MD, Jin F, Nieman DC. Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol Res 2010;62:237-42.
Denny Joseph KM, Muralidhara. Enhanced neuroprotective effect of fish oil in combination with quercetin against 3-nitropropionic acid induced oxidative stress in rat brain. Prog Neuropsychopharmacol Biol Psychiatry 2013;40:83-92.
Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr 2010;140:278-84.
Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, et al.
Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: A randomised double-blinded placebo-controlled cross-over trial. Br J Nutr 2015;114:1263-77.
Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L. Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: A Double-blind Randomized Controlled Clinical Trial. Int J Prev Med 2013;4:777-85.
Shoskes D, Lapierre C, Cruz-Correa M, Muruve N, Rosario R, Fromkin B, et al.
Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: A randomized placebo controlled trial. Transplantation 2005;80:1556-9.
Amirchaghmaghi M, Delavarian Z, Iranshahi M, Shakeri MT, Mosannen Mozafari P, Mohammadpour AH, et al.
A Randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus. J Dent Res Dent Clin Dent Prospects 2015;9:23-8.
| Authors|| |
Dr. Alexander Victor Anand David, Is a Lecturer in Unit of Anatomy, Faculty of Medicine, AIMST University, Malaysia. He obtained his M.B.B.S., degree from Mysore University and M.Sc., (Human Anatomy) degree from AIMST University. His research interest is histopathological study, musculoskeletal disorders, forensic and clinical anatomy.
Dr. Radhakrishnan Arulmoli, Is a Professor and Head of Unit, Unit of Anatomy, Faculty of Medicine, AIMST University, Malaysia.
Dr. Subramani Parasuraman, Is a Senior Lecturer, Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Malaysia. His research interest is in the areas of pre-clinical pharmacodynamics and toxicological studies.
[Table 1], [Table 2]