Home | About us | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Reviews
Search Article 
Advanced search 

 Table of Contents  
Year : 2012  |  Volume : 6  |  Issue : 11  |  Page : 68-73  

Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India

Date of Submission10-Dec-2010
Date of Decision02-Apr-2011
Date of Web Publication08-May-2012

Correspondence Address:
Alakh N Sahu
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi - 221005
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-7847.95893

Rights and Permissions

Medicinal plants are widely being used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Biophytum sensitivum DC (Oxalidaceae) is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea. It is a small, flowering, annual herb with sensitive leaves. It grows throughout tropical Africa and Asia, especially in Philippines and the hotter parts of India and Nepal. Phytochemical studies have shown that the major pharmacologically active constituents are amentoflavone and a polysaccharide fraction, BP100 III. Recent pharmacological study shows that it has antioxidant, immunomodulatory, anticancer, anti-inflammatory, chemoprotective, antidiabetic and wound healing potential. This review attempts to describe the ethnobotany, pharmacognosy, traditional uses, chemical constituents, and various pharmacologic activities and other aspects of B. sensitivum.

Keywords: Amentoflavone, angiogenesis, Biophytum sensitivum, seismonasty

How to cite this article:
Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Phcog Rev 2012;6:68-73

How to cite this URL:
Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Phcog Rev [serial online] 2012 [cited 2019 Mar 22];6:68-73. Available from: http://www.phcogrev.com/text.asp?2012/6/11/68/95893

   Introduction Top

Traditional medicines still remain the main resource for a large majority of people treating health problems. Biophytum sensitivum DC (Oxalidaceae) is a small, sensitive annual herb, growing throughout the tropical regions of South Asia, Africa and Madagascar. This "little tree plant" is known for its interesting characteristic similar to the touch-me-not plant. The medicinal plant is used traditionally in a number of ailments, such as joint pains, inflammations, fever, malaria, wounds, stomach ache, diabetes, gonorrhea, tuberculosis, convulsion, thirst, tumor, burns, asthma, phthisis, snake bite, insomnia, arthralgia, arthritis, back pain, bone spur, bursitis, carpal tunnel syndrome, cervical spondylitis, degenerative joint disease, degenerative neck disease, fibromyalgia and leg cramps. [1],[2],[ 3] It is commonly known as Lajjaluka in Sanskrit, as it can be observed as inward curling of its leaves in response to touch stimuli. The Mukkutti (flowers) are significant for the people of Kerala, both for its medicinal and for its cultural and traditional values. During the national festival of Onam in Kerala, intricate and colorful arrangements of its flowers laid on the floor, called Pookalam, are made.

Generally, the whole plant is frequently used for medicinal purpose. But an ethnopharmacological survey of six medicinal plants in Mali and West Africa showed that most of the traditional preparations are made from leaves. [4]

   Ayurvedic Properties Top

Rasa: Katu

Guna: Lakhu, Ruksha

Virya: Ushna [5]

It is medicinally used in traditional Ayurvedic and Siddha systems. It is one of the auspicious herbs that constitute the group "Dasapushpam", an Ayurvedic formulation. [6] Ayurveda recommends its powder in gonorrheal infection and lithiasis and the decoction is advised for amenorrhea and dysmenorrhea. Powder with honey is indicated in Ayurveda for abnormal growths, glandular swellings, especially for hypothyroidism; grounded leaves with water show diuretic effect and relieve thirst in yellow fever. In Philippines, decoction of the leaves is used as an expectorant and in Java it is used for asthma. In Siddha system, the grounded leaves are given along with butter milk for diarrhea, grounded seeds are applied over wound and ulcer, the samoolam of this plant is mixed with honey and given for cough and chest congestion, and paste of the leaves is applied over burns and contusions. [7] Mixture of powder with salt and red oil is eaten periodically for epilepsy in Cameroon.

   Habitat Top

It is found in wetlands, plains of tropical Africa and Asia, mainly Philippines, and normally grows in shade of trees, at a low and medium altitude and is distributed throughout the hotter parts of India, Nepal, Thailand, Malaysia, Indonesia and Sri Lanka. [8] B. sensitivum is easily propagated from seeds. It thrives on rich soil that is slightly acidic in pH. The plants grow in damp soil. Watering in winter has to be reduced, but the soil should not be allowed to dry. It requires a temperature of 16°C-29°C and medium humidity. Flowering occurs from August to January. [9]


Common name: Life plant, little tree plant, sensitive plant

French: alleluya

Bengali: Jhalai

Hindi: Lajalu, Lajjaalu, Lakshmana, Zarer

Indo-China: Chua me

Kannada: Haramuni, Jalapushpa

Malayalam: Mukkutti

Marathi: Jharera, Lajwanti, Lahanmulaka

Sanskrit: Jhullipuspa, Lajjaluka, Panktipatra, Pitapushpa, Vipareetalajjaalu

Tamil: Nilaccurunki, Tintaanaalee

Telugu: Attapatti, Chumi, Jala pupa [10]

Taxonomical classification

Kingdom: Plantae

Phylum: Tracheophyta

Class: Magnoliposida

Order: Oxalidales

Family: Oxalidaceae

Genus: Biophytum

Species: sensitivum

Botanical name: Biophytum sensitivum (L.) DC [11]

   Botanical Description Top

It is an annual herb which looks like a miniature palm, with unbranched, erect, glabrous or hairy stems from 2.5 to 25 cm. Leaves are sensitive, pinnately compound, crowded into rosette on top of stem, and 5-12 cm long, with 6-12 pairs of leaflets. The leaflets are opposite, petiole is short, gradually increases in size upward, being 1.5 cm long, oblong and apiculate at apex. Flowers are dimorphic, 8 mm across yellow peduncle, many, and up to 10 cm long. Sepals are 5, lanceolate, imbricate, and acute with parallel nerves. Petals are 5, yellow with red marking, connate into salver shaped corolla and much exceeding the sepals, lobes rounded. The fruit is a capsule which is ellipsoid, apiculate, slightly exceeding the sepals. Seeds are ovoid and transversely striate. Stamens are 10, distinct filament free, the five inner ones are longer and styles are five. [8],[12] The fundamental vascular structure of both stem and petiole consists of a circle of collateral bundles, and is often accompanied externally by a sclerenchymatous ring in pericycle. As the name of family implies, oxalic acid is very common in tissue, where it is believed to occur in the form of dissolved potassium oxalate crystals as well as being secreted as calcium oxalate, usually in the form of small solitary cubical and crystal cell. These cells accompany and form sheath to the vascular bundles of the vein in B. sensitivum. Leaflets are usually dorsiventral having glandular hair, stalk of varying lengths and unicellular heads. Stomata are rubiacious with at least one and sometimes two subsidiary cells parallel to the pore. Vascular bundles of the vein are provided with enlarged terminal tracheids. The TS of stem shows pericycle bounded by composite and more or less continuous ring of sclerenchyma. [13]


Biophytum shows nastic movement in leaves in response to touch, contact with foreign body, drop of rain, wind, vibration, heat and closes its leaflets and the movement is independent of direction of the stimulus. Degree of movement varies according to intensity of stimulus applied. When the leaf apex of sensitive plant is touched lightly, only a few pairs of leaflets close up, and when roughly touched, all the leaflets react in the same way from the apex downward. The pulvinus is a motor structure consisting of a rod of sclerenchyma surrounded by collenchymas. In its extended position, the cells of the entire collenchymas are distended with water, and on receiving the action potential signal by touch, the cells in the lower half of the pulvinus respond by expelling potassium and chlorine ions and taking up calcium ions. This results in an osmotic gradient that draws water out of the affected cells. The lower pulvinus cells temporarily shrink due to water loss. This forces the entire structure to curve down in the manner of a fan. In this contracted position, the pulvinus no longer functions as a support and the petiole droops. [14],[15] In addition, botanists have discovered signaling molecule called turgorin which is thought to be a new class of phytohormone regulating all the leaf movements by controlling the turgor of plant cells. The turgorin molecule contains a strongly acidic, free sulfuric acid group and it was found that diluted sulfuric acid induced leaf closing as strongly as turgorin. Hence, it was concluded that the leaf-closing activity of turgorin is due to the strong acidity of its sulfuric acid group. [16]

   Phytoconstituents Top

Phytochemical studies of B. sensitivum showed that it contains a number of phenolic and polyphenolic compounds, saponin, essential oil, polysaccharides and pectin. The main bioactive constituents found are bioflavonoid, amentoflavone [Figure 1] with minute amount of cupressoflavone. Quantification of amentoflavone by reversed phase high performance liquid chromatography (HPLC) in methanolic extract of roots, stems and leaves revealed the amounts to be 0.26% in roots, 0.33% in stems, and 0.012% in leaves. Aqueous extract showed much smaller quantities of these phytoconstituents. [17] Other than amentoflavone, the flavonols present were luteolin 7-methyl ether, isoorientin [Figure 2], 3′-methoxyluteolin 7-O-glucoside, as well as two acids, 4-caffeoylquinic acid and 5-caffeoylquinic acid, that were isolated from aerial parts of B. sensitivum.[18] Further isolation and quantification of C-glycosyl flavones and proanthocynidin from the plant showed the presence of isoorientin, orientin [Figure 3], isovitexin [Figure 4], isoorientin 7-O-glucoside, isoorientin 2″-O-rhamnoside in methanolic extract of the leaves. From the roots, (−)-epicatechin [Figure 5] and epicatechin-(4β-8)-epicatechin (proanthocynidin B2) were isolated and the highest amount of C-glycosyl flavones was found in leaves. [19] The essential oil of air-dried B. sensitivum was investigated by gas chromatography-spectroscopy (GC-FID and GC-MS) and was found to contain mainly 1,4-dimethoxy benzene (24.9%), 1,2-dimethoxy benzene (10.6%) [Figure 6] and 2-methoxy-4-methyl phenol [Figure 7] (3.5%), the monoterpenes (Z)-linalool oxide (8.1%) [Figure 8], (E)-linalool oxide (5.2%), linalyl acetate (3.4%) [Figure 9], 1-octen-3-ol (9.5%), isophorone (3.1%), and 69 minor compounds. [20] The water extract of aerial parts [Figure 10] contains a bioactive polysaccharide, BP100 III, major part of which is composed of galacturonic acid and rhamnose, with branches being present on both the rhamnose and galacturonic acid residues. [21]
Figure 1: Amentofl avone

Click here to view
Figure 2: Isoorientin

Click here to view
Figure 3: Orientin

Click here to view
Figure 4: Vitexin

Click here to view
Figure 5: Epicatechin

Click here to view
Figure 6: 1,2 dimethoxy benzene

Click here to view
Figure 7: 2,methoxy 4-methyl phenol

Click here to view
Figure 8: Linalool oxide

Click here to view
Figure 9: Linalyl acetate

Click here to view
Figure 10: Isophorone

Click here to view

Chemical structures of some important constituents of Biophytum sensitivum

Pharmacological activities

Biochemical and pharmacological research has shown B. sensitivum to possess a number of potential pharmacological activities which are summarized below.

Antioxidant activity

B. sensitivum has significant antioxidant activity both in vitro and in vivo. An extract of B. sensitivum was found to scavenge superoxide radicals generated by the photoreduction of riboflavin and hydroxyl radicals generated by the Fenton reaction and inhibited in vitro lipid peroxidation at concentrations of 50, 95, and 20 mg/ml [50% inhibition (IC50)], respectively. The drug also scavenged nitric oxide (NO; IC50 = 100 mg/ml). The extract also induced the dose-dependent scavenging of NO in culture. Intraperitoneal administration of Biophytum extract inhibited superoxide generation in macrophages in vivo. The administration of B. sensitivum to mice significantly increased the catalase activity. The extract produced a significant increase in glutathione levels in blood and liver. The levels of glutathione-S-transferase and glutathione reductase increased and that of glutathione peroxidase decreased after administering the Biophytum extract. [22]

Anti-inflammatory activity

Amentoflavone (I3', II8-biapigenin) was isolated from the roots of B. sensitivum DC (Oxalidaceae) and proved to be a selective inhibitor of cycloxygenase (COX)-1 catalyzed prostaglandin biosynthesis when tested in vitro, with an IC50 value of 12.4 mM (standard: indomethacin, IC50 = 1.1 mM). [17] The dose-dependent study indicated that prostaglandin E2 (PGE2) production was inhibited both at 10 and 50 mM concentrations of amentoflavone by 52 and 55.5%, respectively. Inhibitory effects of amentoflavone on PGE2 biosynthesis and on NO production were associated with COX-2 and iNOS mRNA expression, by a rise in NO and corresponding enzyme. [23] A comparative study was done in the carrageenan-induced rat paw edema model. It was found that the aqueous extract had maximum edema inhibition in comparison to the methanolic extract of root and aerial part. [24]

Antidiabetic activity

B. sensitivum shows hypoglycemic activity. In alloxan-diabetic rabbits, initial dose-response studies showed that a dose of 200 mg/kg body weight (b.wt.) was optimum for hypoglycemia. A single administration of this dose to 16-h fasted non-diabetic rabbits brought about a 16.1% fall in fasting plasma glucose (FPG) level at the end of 1 h and 2 h, and the hypoglycemic effect persisted at the end of 6 h (13.8% fall). The study also showed rise in serum insulin levels in the treated animals, suggesting a pancreatic mode of action (i.e. insulinotropic effect) of B. sensitivum. [25] Hypoglycemic effect was studied in the alloxan diabetic male rabbits of different severities: subdiabetic (alloxan recovered; AR), mild diabetic (MD) and severely diabetic (SD). Following single dose administration, there was fall in 1 h and 2.5 h glucose values by 25.9% and 27.4%, respectively, in the subdiabetic rabbits, and by 36.9% and 37.7%, respectively, in the mild diabetic rabbits. [26]

Anti-angiogenic activity

Amentoflavone from B. sensitivum at nontoxic concentrations (0.05-0.2 mg/ml) showed significant inhibition of proliferation, migration, and tube formation of endothelial cells, which are the key events in the process of angiogenesis. In vivo studies in C57BL/6 mice showed remarkable inhibition (52.9%) of tumor-directed capillary formation and also controlled the production of various factors such as interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, granulocyte macrophage-colony stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) involved in angiogenesis, thus resulting in anti-angiogenic effect by disrupting the integrity of endothelial cells. [27]

Anticancer effect

Amentoflavone at a concentration of 10 mg/ml significantly (P < 0.001) inhibited NO and proinflammatory cytokine (IL-1β, IL-6, GM-CSF and TNF-α) production in B16F-10 cells, tumor-associated macrophages (TAMs) and peritoneal macrophages. Further study showed that amentoflavone stimulates apoptosis by regulating bcl-2, caspase-3 and p53 genes in B16F-10 melanoma cells. [28] In a recent study by Guruvayoorappan on amentoflavone treatment, it was found to significantly lower the number of lung nodules (P < 0.001) and markedly decrease the mRNA expression of MMP-2, MMP-9, prolylhydroxylase, lysyl oxidase, VEGF, extracellular regulated kinase (ERK)-1, ERK-2, TNF-α, IL-1b, IL-6, and GM-CSF in lung tissues. [29] B. sensitivum treatment significantly reduced lung tumor nodule formation, accompanied by reduced lung collagen hydroxyproline, hexosamine, and uronic acid levels, and downregulated the expression of matrix metalloprotease-2 and -9 and at the same time upregulated the lung tissue inhibitor of metalloprotease-1 and -2 expression. [30]

Chemoprotective effect

An alcoholic extract of B. sensitivum was studied against cyclophosphamide (CTX) induced toxicity in mice. Intraperitoneal (IP) administration of the extract with CTX significantly increased the total WBC count (3356 ± 236 cells/cm 2 ), bone marrow cellularity (15.6 ± 0.42 cells/femur) and α-esterase positive cells (846 ± 30 cells) when compared to control mice treated with CTX alone and also increased the relative organ weight of the spleen and thymus. Further histopathologic analysis of the small intestine also suggested that B. sensitivum could reduce CTX-induced intestinal damage. [31]

Immunomodulatory effect

Administration of B. sensitivum extract (500 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the lifespan of mice bearing Ehrlich ascites carcinoma tumors by 93.3%. The treatment significantly decreased the glutathione level (GSH), serum glutamyl transpeptidase (GGT) activity, and NO level and increased the WBC count, bone marrow cellularity and beta-esterase positive cell. [32] In another study, the methanol extract of B. sensitivum regulated the production of IL-1β, TNF-α, IL-6, and NO in vitro and in vivo. The extract inhibited the production of NO and proinflammatory cytokines in lipopolysaccharide (LPS) or concanavalin (Con) A-stimulated primary macrophages. [33]


The radioprotective effect of methanolic extract of was studied using in vivo mice models. They were exposed to whole body gamma irradiation (6 Gy/animal) after treatment with B. sensitivum (50 mg/kg b.wt.), which was followed by estimation that showed reduced levels of alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT) and lipid peroxide (LPO) levels, and enhanced glutathione (GSH) content in liver and intestinal mucosa. [34]

Wound healing

Water extract of B. sensitivum has been traditionally used for wound healing and immunomodulatory activity. Recent study has shown that the aqueous extract of aerial part has the polysaccharide fraction, BP100 III, and has a monosaccharide composition typical of pectic substances, that exhibits potent dose-dependent complement fixating activity. The highest molecular weight fraction of BP 100 III is BP 100 III.1 which has more potent activity in the complement test system than the native polymer, while the two lower molecular weight fractions are less active than the native polymer. The major part of the BP100 III.1 consists of galacturonic acid and rhamnose sugar having additional arabinogalactan type II in polymer.

   References Top

1.Visharad SB. Vanausadhi Chandroday. An encyclopaedia of Indian botaniseand herbs, (6-10). Varanasi:Chaukhmbha Sanskrit Sansthan;2003.p. 23-4.  Back to cited text no. 1
2.Dr . Duke's Phytochemical and Ethnobotanical Database.Available from: http://www.ars-grin.gov/cgi-bin/duke/ethnobot.pl. [Last updated on 1998 Mar10; cited on 2010 July 15]  Back to cited text no. 2
3.Council of scientific and industrial research; The Wealth of India, A dictionary of Indian raw material and industrial product, Raw material. Vol.1. Delhi; 1948. p. 187.  Back to cited text no. 3
4.Gronhaug TE, Glaeserud S, Skogsrud M, Ballo N, Bah S, Diallo D, et al. Ethnopharmacological survey of six medicinal plants from Mali, West. J Ethnobiol Ethnomed 2008;4:26.   Back to cited text no. 4
5. Kamat SD. Studies on medicinal plant and drugs in Dhanvantari Nighantu. Delhi: Chakhamba Sanskrit Pratishthan; 2002. p.  344- 7.  Back to cited text no. 5
6.Joy PP, Thomas J, Mathew S, Skaria BP. Medicinal Plants: Tropical Horticulture. Vol. 2. Bose TK, Kabir J, Das P,Joy PP, editor. Calcutta: Naya Prakash;2001.p. 449-632.  Back to cited text no. 6
7.Biophytum sensitivum or Mukkutty. Available from: http://siddham.in/mukkutty-Biophytum-sensitivum.[Last updated on 2010 June 26; cited on 2010 Aug 9].  Back to cited text no. 7
8.Kritikar KR, Basu BD. Indian medicinal plant. Vol. 1. 2nd ed. 1935.  p. 240-1.  Back to cited text no. 8
9.Biophytum sensitivum (Oxalidaceae) at the culture sheet. Available from: http://culturesheet.org/doku.php?id=oxalidaceae:Biophytum:Sensitivum.[Last cited on 2010 July 30].  Back to cited text no. 9
10.Editorial Committee of the Flora of Taiwan; Flora of Taiwan, 2 nd  ed. 1993.  Back to cited text no. 10
11.Biophytum sensitivum var. assamicum (life plant). Available from: http://zipcodezoo.com/Plants/Biophytum_sensitivum. [Last updated on 2009 Apr 1; cited on 2010 Aug 28].  Back to cited text no. 11
12.Veena CS, Sreedevi P. Floral biology and pollination in,Biophytum sensitivum (L.) DC (Oxalidaceae). J Palynol2007;43:21-38.  Back to cited text no. 12
13.Metcalfe CR, Chattaway MM, Hare CL, Richardson FR, Slatter EM, Chalk L. Anatomy of the dicotyledons : Leaves, stem, and wood in relation to taxonomy, with notes on economic uses.1950;1:724.  Back to cited text no. 13
14.Dutta AC, Dutta TC. Botany for Degree Students. 6 th ed.Oxford:Oxford University Press;1997.p.724.  Back to cited text no. 14
15.Sibaoka T. Transmission of action potentials in Biophytum. J Plant Res1973;86:51-86.  Back to cited text no. 15
16.Ueda M, Sugimoto T, Sawai Y, Ohnuki T, Yamamura S. Chemical studies on plant leaf movement controlled by a biological clock.Pure Appl Chem 2003;75:353-8.  Back to cited text no. 16
17.Bucar F, Jachak SM, Noreem Y, Karting T, Perera P, Bohlin L, et al. Catalysed prostaglandin M. Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2biosynthesis. Planta Med1998;64:373-4.  Back to cited text no. 17
18.Yun-Lian L, Wan-Yi W.Chemical constituents of Biophytum sensitivum.Chin Pharm J (Taipei, Taiwan) 2003;55:71-5.  Back to cited text no. 18
19.Bucar F, Jachak SM, Kartnig T, Schubert-Zsilavecz M. Phenolic compounds from Biophytum sensitivum. Pharmazie 1998;53:651-3.   Back to cited text no. 19
20.Leopold J, Gerhard B, Andrea W, Mohamed SP, Beena J. Medicinally used plants from India: Analysis of the essential oil of air-dried Biophytum sensitivum (L.) DC. Sci Pharm 2004;72:87- 96.  Back to cited text no. 20
21.Inngjerdingen KT, Coulibaly A, Diallo D, Michaelsen TE, Paulsen BS. A Complement Fixing Polysaccharide from Biophytum petersianum Klotzsch, a Medicinal Plant from Mali, West Africa. Biomacromolecules 2006;7:48-53.  Back to cited text no. 21
22.Guruvayoorappan C, Afira AH, Kuttan G. Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. J Basic Clin Physiol Pharmacol 2006;17:255-67.  Back to cited text no. 22
23.Banerjee T, Van der Vliet A, Ziboh VA. Down regulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostaglandins Leukot Essent Fatty Acids 2002;66:485-92.  Back to cited text no. 23
24.Jachak SM, Bucar F, Kartnig T. Anti-inflammatory activity of extracts Biophytum sensitivum in carrageen in-induced rat paw oedema. Phytother Res1999;13:73-4.  Back to cited text no. 24
25.Puri D. The insulintropic activity of a Nepalese medicinal plant Biophytum sensitivum: Preliminary experimental study. J Ethnopharmacol 2001;78:89-93.  Back to cited text no. 25
26.Puri D. Screening of mildly hypoglycaemic compounds: Obese British Angora rabbits with borderline glucose intolerance as animal model. Indian J Pharm Sci 2006;68:579-83.  Back to cited text no. 26
  Medknow Journal  
27.Guruvayoorappan C, Kuttan G. Inhibition of tumour specific angiogenesis by amentoflavone . Biochemistry (Mosc) 2008;73:209-18.  Back to cited text no. 27
28.Guruvayoorappan C, Kuttan G. Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumour associated macrophages and peritoneal macrophages.J Exp Ther Oncol2008;7:207-18.   Back to cited text no. 28
29.Guruvayoorappan C, Kuttan G. Amentoflavone Inhibits Experimental Tumor Metastasis Through a Regulatory Mechanism Involving MMP-2, MMP-9, Prolyl Hydroxylase, Lysyl Oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and Cytokines in Lung Tissues of C57BL/6 mice. Immunopharmacol Immunotoxicol 2008;30:711-27.  Back to cited text no. 29
30.Guruvayoorappan C, Kuttan, G. Anti-metastatic effect of Biophytum sensitivum is exerted through its cytokine and Immunomodulatory activity and its regulatory effect on the activation and nuclear translocation of transcription factors in B16F-10 melanoma cells. J ExpTherOncol2008;7:49-63.  Back to cited text no. 30
31.Guruvayoorappan C, Kuttan G. Evaluation of the chemoprotective effect of Biophytum sensitivum (L.) DC extract against cyclophosphamide induced toxicity in Swiss albino mice. Drug Metabol Drug Interact 2006;22:131-50.  Back to cited text no. 31
32.Guruvayoorappan C, Kuttan G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pac JCancer Prev 2007;8:27-32.  Back to cited text no. 32
33.Chandrasekharan C, Kuttan G.Methanol Extract of Biophytum sensitivum Alters the Cytokine Profile and Inhibits iNOS and COX-2 Expression in LPS/Con A Stimulated Macrophages. Drug Chem Toxicol 2008;31:175-88.  Back to cited text no. 33
34.Guruvayoorappan C, Kuttan G. Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice. Immunopharmacol Immunotoxicol 2008;30:815-35.  Back to cited text no. 34


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10]

This article has been cited by
1 Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells
Arathy Raju,Shantikumar V. Nair,Vinoth-Kumar Lakshmanan
IET Nanobiotechnology. 2017;
[Pubmed] | [DOI]
2 Extracellular Signal-Regulated Kinase Is a Direct Target of the Anti-Inflammatory Compound Amentoflavone Derived from Torreya nucifera
Jueun Oh,Ho Sik Rho,Yanyan Yang,Ju Young Yoon,Jongsung Lee,Yong Deog Hong,Hyeon Chung Kim,Sun Shim Choi,Tae Woong Kim,Song Seok Shin,Jae Youl Cho
Mediators of Inflammation. 2013; 2013: 1
[Pubmed] | [DOI]
3 Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera
Oh, J., Rho, H.S., Yang, Y., Shin, S.S., Cho, J.Y.
Mediators of Inflammation. 2013; 2013
4 Anti-Arthritic and anti-inflammatory constituents from medicinal plants
Murugananthan, G. and Sudheer Kumar, G. and Sathya Chethan, P. and Mohan, S.
Journal of Applied Pharmaceutical Science. 2013; 3(4): 161-164


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
   Ayurvedic Properties
    Botanical Descri...
    Article Figures

 Article Access Statistics
    PDF Downloaded20    
    Comments [Add]    
    Cited by others 4    

Recommend this journal