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Year : 2011  |  Volume : 5  |  Issue : 9  |  Page : 19-29  

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra - 136 119, Haryana, India

Date of Submission15-May-2010
Date of Web Publication6-Apr-2011

Correspondence Address:
Vipin Kumar
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra -136 119, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-7847.79096

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Diabetes is a common metabolic disease characterized by abnormally high plasma glucose levels, leading to major complications, such as diabetic neuropathy, retinopathy, and cardiovascular diseases. One of the effective managements of diabetes mellitus, in particular, non-insulin-dependent diabetes mellitus (NIDDM) to decrease postprandial hyperglycemia, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as α-glucosidase and α-amylase, in the digestive organs. α-Glucosidase is the key enzyme catalyzing the final step in the digestive process of carbohydrates. Hence, α-glucosidase inhibitors can retard the liberation of d-glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postprandial hyperglycemia. In recent years, many efforts have been made to identify effective α-glucosidase inhibitors from natural sources in order to develop a physiologic functional food or lead compounds for use against diabetes. Many α-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants. In the present review, we focus on the constituents isolated from different plants having α-glucosidase inhibitory potency along with IC50 values.

Keywords: Alkaloids, anthocyanins, diabetes, flavonoids, α-glucosidase, glycosides, terpenoids

How to cite this article:
Kumar S, Narwal S, Kumar V, Prakash O. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Phcog Rev 2011;5:19-29

How to cite this URL:
Kumar S, Narwal S, Kumar V, Prakash O. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Phcog Rev [serial online] 2011 [cited 2019 Sep 18];5:19-29. Available from: http://www.phcogrev.com/text.asp?2011/5/9/19/79096

   Introduction Top

Diabetes mellitus is the most serious, chronic metabolic disorder and is characterized by high blood glucose levels. One therapeutic approach to treat diabetes is to retard the absorption of glucose via inhibition of enzymes, such as α-glucosidase, in the digestive organs. [1],[2] α-Glucosidase (α-d-glucoside glucohydrolase) is an exo-type carbohydrase distributed widely in microorganisms, plants, and animal tissues,[3] which catalyzes the liberation of α-glucose from the non reducing end of the substrate. Inhibiting this enzyme slows the elevation of blood sugar following a carbohydrate meal. [4] It is a membrane bound enzyme present in the epithelium of the small intestine, which works to facilitate the absorption of glucose by the small intestine by catalyzing the hydrolytic cleavage of oligosaccharides into absorbable [Figure 1] monosaccharides. [5]
Figure 1: Conversion of oligosaccharide to glucose

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By the inhibition of α-glucosidase in the intestine, the rate of hydrolytic cleavage of oligosaccharide is decreased and the process of carbohydrate digestion spreads to the lower part of small intestine. This spreading of digestion process delays the overall absorption rate of glucose into the blood. This has proved to be one of the best strategies to decrease the postprandial rise in blood glucose and in turn help avoiding the onset of late diabetic complications. [5]

There are reports of the presence of α-glucosidase inhibitors, such as acarbose [6],[7] andvoglibose, [8] in microorganisms, and nojirimycin [9],[10],[11] and 1-deoxynojirimycin [11] in plants, as well as the effects of α-glucosidase inhibitor in wheat kernels on blood glucose levels after food uptake. [12]

α-Glucosidase inhibitory potency of plant extracts and isolated compounds from different origins are discussed in [Table 1].
Table 1: Extracts/phytoconstituents having α -glucosidase inhibition activity

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   α-Glucosidase Inhibition by Flavonoids Top

The inhibitory activity of six groups of flavonoids against α-glucosidase in yeast and rat small intestine was compared, and the chemical structures of flavonoids responsible for the inhibitory activity were evaluated. Yeast α-glucosidase was potently inhibited by the anthocyanidin, isoflavone, and flavonol groups with the IC50 values less than 15 μM. Rat's small intestinal α-glucosidase was weakly inhibited by many flavonoids, and slightly by the anthocyanidin and isoflavone groups.[13]

All the six groups of flavonoids with their chemical structures [Figure 2].
Figure 2: Some of the phytochemicals with their chemical structures

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One flavonoid glycoside, quercetin 3-O-β-d-xylopyranosyl (1'''→2″)-β-d-galactopyranoside(7) from Alstonia scholaris inhibited only maltase with IC 50 values of 1.96 mM. [14]

   Alkaloids Top

Methanolic extract of Adhatoda vasica Nees was tested in screening experiments for rat intestinal α-glucosidase. Vasicine (8) and Vasicinol (9), which were isolated by assay-guided fractionation of this extract, showed a high sucrase inhibitory activity with IC 50 values 125 and 250 μM, respectively. Both of these compounds were shown to be reversible inhibitors of sucrase. [15]

Three alkaloids named piperumbellactam A (10), piperumbellactam B (11) and piperumbellactam C (12) were isolated from branches of Piper umbellatum and these compounds showed moderate α-glucosidase enzyme inhibition with IC 50 values 98.07 ± 0.44, 43.80 ± 0.56, and 29.64 ± 0.46, respectively. [16]

The methanolic extract from flower buds of Tussilago farfara showed the highest maltase inhibitory activity, with maltose as a substrate. Enzyme assay-guided fractionation of this extract afforded 3,4-dicaffeoylquinic acid (13), 3,5-dicaffeoylquinic acid (14), and 4,5-dicaffeoylquinic acid (15). Comparison of the activities of these three compounds with others, such as chlorogenic acid (16), quinic acid (17), and caffeic acid (18), suggested that the number of caffeoyl groups attached to a quinic acid core were important for the potency. [17]


The dried Terminalia chebula (Combretaceae) fruits were extracted using 70% methanol at room temperature and its mammalian α-glucosidase inhibitory activity was investigated. It was found to have a potent rat intestinal maltase inhibitory activity. Three active ellagitannins, identified as chebulanin (19), chebulagic acid (20), and chebulinic acid (21) were isolated using bioassay-guided separation. All the three compounds were shown to possess potent intestinal maltase inhibitory activity with IC 50 values of 690, 97, and 36 μM, respectively. [18]

The extraction and fractionation of 50% aqueous methanolic extracts of Bergenia cilata led to the isolation of two active compounds, namely, (-)-3-O-galloylepicatechin (22) and (-)-3-O-galloylcatechin (23). These isolated compounds demonstrated significant dose dependent enzyme inhibitory activities against rat intestinal α-glucosidase. The IC 50 values of (-)-3-O-galloylepicatechin are 560 and 334 μM for sucrose and maltase, respectively, and that of (-)-3-O-galloylcatechin are 297 and 150 μM for sucrose and maltase, respectively. [19]


Two bromophenols, 2, 4, 6-tribromophenol (24) and 2,4-dibromophenol (25), were purified from Grateloupia elliptica. α-Glucosidase inhibitory activity of these compounds against ?-glucosidasesα-glucosidases was determined compared with acarbose and voglibose. The IC 50 values of compounds (24) and (25) against Saccharomyces cerevisiae α-glucosidase were 60.3 and 110.4 μM, respectively, which were lower than the 130.3 and 230.3 μM that was presented against the  Bacillus stearothermophilus Scientific Name Search mophilus α-glucosidase.[20] The α-glucosidase inhibitory activities of compound (24) against S. cerevisiae and B. stearothermophilus α-glucosidases were also higher than that for compound (25). [1] It is to be concluded that inhibitory potencies of bromophenol increased with increasing degree of bromo-substitution per benzene ring and with decreasing degree of methyl-substitution. [20] Voglibose and acarbose had high inhibitory effects on mammalian α-glucosidase, but no inhibitory activity against S. cerevisiae α-glucosidase. [21],[22],[23]

Bioassay-guided screening indicated that the defatted EtOH extract of the seeds of Syagrus romanzoffiana showed 55% inhibitory activity against α-glucosidase at a concentration of 10 μg/mL. Further fractionation indicated the active ingredients to be concentrated in the BuOH soluble fraction, having 73% inhibition at 10 μg/mL level. This fraction was further separated over Sephadex LH-20 and low pressure RP-18 columns that eventually yielded eight active compounds Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (26) and scirpusin C (27), possess potent inhibitory activity against α- glucosidase type IV from B. stearothermophilus with the IC 50 value of 6.5 and 4.9 μM, respectively. The IC 50 values of other less potent α-glucosidase inhibitors from this plant are kompasinol A (28) (IC 50 = 11.2), scirpusin A (29) (IC 50 = 8.3), pentahydroxystilbene (30) (IC 50 = 19.2), Piceatannol (31) (IC 50 = 23.2), and resveratrol (32) (IC 50 = 23.9). [24]

One lignan glucoside, (-)-lyoniresinol 3a-O-b-d-glucopyranoside (33), from Alstonia scholaris exhibited an inhibitory activity against both sucrase and maltase with IC 50 values of 1.95 and 1.43 mM, respectively. [14]


Natural curcumin (34), demethoxycurcumin (35) and bisdemethoxycurcumin (36) isolated from Curcuma longa (turmeric) were evaluated in vitro for the α-glucosidase inhibitory activity via UV and circular dichroism spectroscopy. The results indicated that natural curcuminoid compound 36 showed a remarkable inhibitory effect with IC 50 of 23.0 μM. [25]


3b-Acetoxy-16b-hydroxybetulinic acid (37) was isolated from Fagara tessmannii, and it was found to be a potent α-glucosidase inhibitor with IC 50 value 7.6 ± 0.6. [26]

A new triterpenoid saponin Segetalic acid 28-O-α-l-arabinopyranosyl-(1→4)-α-l-arabinopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→2)-β-d-fucopyranosyl ester (38) has been isolated and elucidated from the roots of Gypsophila oldhamiana and has been evaluated for its α-glucosidase inhibition activity with the IC 50 values of about 23.1 ± 1.8 μM. [27]


Cyanidin-3-galactoside (39), a natural anthocyanin, was also investigated for its α-glucosidase inhibitory activity. The IC 50 value of cyanidin-3-galactoside was 0.50 ± 0.05 mM against intestinal sucrase. A low dose of cyanidin-3-galactoside showed a synergistic inhibition on intestinal α-glucosidase (maltase and sucrase) when combined with acarbose. [28]

Maltase (m); Sucrase (s), 2R,3R,4R,5R)2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP); 1-deoxynojirimycin (DNJ)

   Discussion Top

Diabetes is one of the world's greatest health problems, affecting about 171 million people and most of these will be dominated by those suffering from type 2 diabetes. [68] This increasing trend in type 2 diabetes mellitus has become a serious medical concern worldwide, which accounts for 9% of deaths that prompts every effort in exploring for new therapeutic agents to stem its progress. Although the drug treatment for type 2 diabetes mellitus has been improved to some extent during the last decade, drug resistance is still a big concern that needs to be dealt with effective approaches. One of the strategies to monitor blood glucose for type II diabetes mellitus is to either inhibit or reduce the production of glucose from the small intestine. α-Glucosidase inhibitors interfere with the digestion of carbohydrates, achieving better glycemic control. Thus, natural products of great structural diversity are still a good source for searching for such inhibitors, thereby motivating to explore biologically active compounds from the highly diverse plants.

   References Top

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Xuemei Guo,Piaopiao Long,Qilu Meng,Chi-Tang Ho,Liang Zhang
Food Chemistry. 2018; 246: 74
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3 Inhibitory Effects of Siegesbeckia orientalis Extracts on Advanced Glycation End Product Formation and Key Enzymes Related to Metabolic Syndrome
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4 a-Glucosidase inhibitory effect of rhinacanthins-rich extract from Rhinacanthus nasutus leaf and synergistic effect in combination with acarbose
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5 Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1 H -imidazol-1-yl)ethyl aryl ether derivatives, in vitro a -amylase inhibitory activity and in silico studies
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6 Synthesis of Curcumin Analogues Monoketone from Cinnamaldehyde and their Inhibition Assay against Alpha-Glucosidase Enzyme
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7 Identification of Anthocyanins from Four Kinds of Berries and Their Inhibition Activity to a-Glycosidase and Protein Tyrosine Phosphatase 1B by HPLC–FT-ICR MS/MS
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8 Bioassay-guided fractionation and identification of a-amylase inhibitors from Syzygium cumini leaves
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9 Potential of lignin from Canna edulis ker residue in the inhibition of a-d-glucosidase: Kinetics and interaction mechanism merging with docking simulation
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International Journal of Biological Macromolecules. 2017; 95: 592
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10 Understanding of the conformational flexibility and electrostatic properties of coumarin derivatives in the active site of S. cerevisiae a-glucosidase
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11 Effect of in vitro simulated gastrointestinal digestion on polyphenol and polysaccharide content and their biological activities among 22 fruit juices
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12 Jackfruit ( Artocarpus heterophyllus Lam.) peel: A better source of antioxidants and a -glucosidase inhibitors than pulp, flake and seed, and phytochemical profile by HPLC-QTOF-MS/MS
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13 A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica
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Frontiers in Pharmacology. 2017; 8
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14 Dietary Flavonoids and Acarbose Synergistically Inhibit a-Glucosidase and Lower Postprandial Blood Glucose
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15 Reappraisal and perspectives of clinical drug–drug interaction potential of a-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus
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16 Enzyme inhibitory metabolites from endophytic Penicillium citrinum isolated from Boswellia sacra
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17 Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study
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18 Lasianthera Africana leaves inhibits a-amylase a-glucosidase, angiotensin-I converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates
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19 Antibacterial and Hypoglycemic Diterpenoids from Salvia chamaedryoides
Angela Bisio,Maria De Mieri,Luigi Milella,Anna M. Schito,Anita Parricchi,Daniela Russo,Silvana Alfei,Margherita Lapillo,Tiziano Tuccinardi,Matthias Hamburger,Nunziatina De Tommasi
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20 Anti-diabetic xanthones from the bark of Garcinia xanthochymus
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21 Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells
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22 Efficient approach for the extraction of proanthocyanidins from Cinnamomum longepaniculatum leaves using ultrasonic irradiation and an evaluation of their inhibition activity on digestive enzymes and antioxidant activity in vitro
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23 Probing the influence of carboxyalkyl groups on the molecular flexibility and the charge density of apigenin derivatives
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24 Evaluation of debittered and germinated fenugreek (Trigonella foenum graecum L.) seed flour on the chemical characteristics, biological activities, and sensory profile of fortified bread
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25 Differential a-amylase/a-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes
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26 New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft
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27 a-Glucosidase inhibitory effect of Potentilla astracanica and some isoflavones: Inhibition kinetics and mechanistic insights through in vitro and in silico studies
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28 Inhibitory Potential of Red Cabbage against Digestive Enzymes Linked to Obesity and Type 2 Diabetes
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29 Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies
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30 In vitro antioxidant activities of African birch (Anogeissus leiocarpus) leaf and its effect on the a-amylase and a-glucosidase inhibitory properties of acarbose
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31 Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities
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32 Potential of Rooibos, its MajorC-Glucosyl Flavonoids andZ-2-(ß-D-Glucopyranoloxy)-3-phenylpropenoic acid in Prevention of Metabolic Syndrome
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33 Chemistry, Pharmacology and Health Benefits of Anthocyanins
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34 Acute toxicity and hypoglycaemic activity of the leaf extracts of Persea americana Mill. (Lauraceae) in Wistar rats
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35 Screening for potential a-glucosidase and a-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes
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36 In vitroeffects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2
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37 In VitroandIn Vivoa-Glucosidase and a-Amylase Inhibitory Effects of the Water Extract of Leaves of Pepper (Capcicum AnnuumL. CultivarDangjo) and the Active Constituent Luteolin 7-O-Glucoside
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38 Potential sources for the management global health problems and oxidative stress: Stachys byzantina and S. iberica subsp. iberica var. densipilosa
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39 A new megastigmane sulphoglycoside and polyphenolic constituents from pericarps ofGarcinia mangostana
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40 Anti-inflammatory, free radical scavenging and alpha-glucosidase inhibitory activities ofHamelia patensand its chemical constituents
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41 The effect of oatß-glucan onin vitroglucose diffusion and glucose transport in rat small intestine
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43 Screening of minor bioactive compounds from herbal medicines by in silico docking and the trace peak exposure methods
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44 Oleanolic, Ursolic and Betulinic Acids as Food Supplements or Pharmaceutical agents for Type 2 Diabetes – Promise or Illusion?
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45 Inhibitory kinetics and mechanism of kaempferol on a-glucosidase
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46 Structure and histochemistry of medicinal species of Solanum
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47 Antidiabetic Potential of Potentilla fulgens Roots in Validated Animal Models of Diabetes
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48 Renal biochemical and histopathological alterations of diabetic rats under treatment with hydro alcoholic Morus nigra extrac
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49 Antidiabetic studies of Chaetomorpha antennina extract using experimental models
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50 a-Glucosidase inhibiting activity and bioactive compounds of six red wine grape pomace extracts
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51 Artemisia annuaLeaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice
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52 Biological activities of unique isoflavones prepared fromApios americanaMedik
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53 FT-IR analysis of Sapium ellipticum (Hochst) pax ethanol leaf extract and its inhibitory effects on pancreatic a-amylase and intestinal a-glucosidase activities in vitro
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54 Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels
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55 Concise synthesis of a new triterpenoid saponin from the roots of Gypsophila oldhamiana and its derivatives as a-glucosidase inhibitors
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56 Tomato plant leaves: From by-products to the management of enzymes in chronic diseases
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57 Phytosterols in banana (Musa spp.) flower inhibit a-glucosidase and a-amylase hydrolysations and glycation reaction
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58 Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves
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59 Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity and glucosidase inhibitory activity of compounds isolated fromAgrimonia pilosa
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60 Postprandial effects of a polyphenolic grape extract (PGE) supplement on appetite and food intake: a randomised dose-comparison trial
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61 New a-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs
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62 Structure activity related, mechanistic, and modeling studies of gallotannins containing a glucitol-core and a-glucosidase
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63 Effect of Black Tea and Black Tea Pomace Polyphenols on α-Glucosidase and α-Amylase Inhibition, Relevant to Type 2 Diabetes Prevention
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64 Structural and phylogenetic analysis of a-glucosidase protein in insects
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65 Screening and structural characterization of potential a-glucosidase inhibitors from Radix Astragali flavonoids extract by ultrafiltration LC-DAD-ESI-MSn
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66 Traditional Chinese Herbal MedicinePenthorum chinensePursh: A Phytochemical and Pharmacological Review
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67 High-resolution bioactivity profiling combined with HPLC–HRMS–SPE–NMR: a-Glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae)
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68 Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects
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69 Hypoglycemic and antioxidant effects of Daraesoon (Actinidia argutashoot) in animal models of diabetes mellitus
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70 Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations
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71 Inhibitory effects of Ligustrum robustum (Rxob.) Blume extract on a-amylase and a-glucosidase
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72 Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of ß-galactosidases
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73 Phenolic Compounds fromOlea europaeaL. Possess Antioxidant Activity and Inhibit Carbohydrate Metabolizing EnzymesIn Vitro
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74 Naturally occurring Batatasins and their derivatives as a-glucosidase inhibitors
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75 Water fraction of edible medicinal fern Stenochlaena palustris is a potent a-glucosidase inhibitor with concurrent antioxidant activity
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76 Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract
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77 Inhibition of a-glucosidase by new prenylated flavonoids from euphorbia hirta L. herb
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78 Inhibitory effect of black tea and its combination with acarbose on small intestinal a-glucosidase activity
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79 Screening of Various Parts ofPhaleria macrocarpaPlant for a-Glucosidase Inhibitory Activity
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80 Inhibitory Properties of Aqueous Ethanol Extracts of Propolis on Alpha-Glucosidase
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81 Management of Diabetic Complications through Fruit Flavonoids as a Natural Remedy
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82 Radical scavenging potentials of single and combinatorial herbal formulations in vitro
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83 Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes
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84 Insulin-Mimetic Selaginellins fromSelaginella tamariscinawith Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity
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85 In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase
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86 a-glucosidase and glycation inhibitory effects of costus speciosus leaves
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88 Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPAR? Signaling Pathway in Porcine Intramuscular Adipocytes
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89 Bioactive Principles from Medicinal Plants
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90 a-glucosidase inhibitory activities of myricetin in animal models of diabetes mellitus
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Food Science and Biotechnology. 2015; 24(5): 1897
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91 Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico
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92 a-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking
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International Journal of Biological Macromolecules. 2014; 64: 213
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93 Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Sung Hoo Jo,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,Young In Kwon,Chau Van Minh,Young Ho Kim
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94 Study of the mechanisms underlying increased glucose absorption inSmilax chinaL. leaf extract-treated HepG2 cells
Yun Hwan Kang,Dae Jung Kim,Kyoung Kon Kim,Sung Mee Lee,Myeon Choe
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95 Phenolic-rich extracts from the edible seaweed, ascophyllum nodosum, inhibit a-amylase and a-glucosidase: Potential anti-hyperglycemic effects
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96 a-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves
Ryuta Yonemoto,Miyuki Shimada,Maria D. P. T. Gunawan-Puteri,Eisuke Kato,Jun Kawabata
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97 Xanthohumol, a Prenylated Chalcone from Beer Hops, Acts as an a-Glucosidase Inhibitor in Vitro
Ming Liu,Hua Yin,Ge Liu,Jianjun Dong,Zhonghua Qian,Jinlai Miao
Journal of Agricultural and Food Chemistry. 2014; 62(24): 5548
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98 Antimicrobial and enzyme inhibitory activities of the constituents ofPlectranthus madagascariensis(Pers.) Benth
Renata Kubínová,Radka Porízková,Alice Navrátilová,Oldrich Farsa,Zuzana Hanáková,Adriana Bacinská,Alois Cížek,Marie Valentová
Journal of Enzyme Inhibition and Medicinal Chemistry. 2014; : 1
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99 Identification of a-glucosidase inhibitors from the leaves ofPluchea indica(L.) Less., a traditional Indonesian herb: promotion of natural product use
Ines Septi Arsiningtyas,Maria D.P.T. Gunawan-Puteri,Eisuke Kato,Jun Kawabata
Natural Product Research. 2014; : 1
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100 Effect of Ca2+ on the activity and structure of a-glucosidase: Inhibition kinetics and molecular dynamics simulations
Xin Zhang,Long Shi,Xuan Li,Qing Sheng,Ling Yao,Dong Shen,Zhi-Rong Lü,Hai-Meng Zhou,Yong-Doo Park,Jinhyuk Lee,Qian Zhang
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101 a-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters
Avin Ramanjooloo,Thierry Cresteil,Cindy Lebrasse,Girish Beedessee,Preeti Oogarah,Rob W.M. van Soest,Daniel E.P. Marie
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102 In Vitro Inhibitory Effect on Digestive Enzymes and Antioxidant Potential of Commonly Consumed Fruits
Anna Podsedek,Iwona Majewska,Malgorzata Redzynia,Dorota Sosnowska,Maria Koziolkiewicz
Journal of Agricultural and Food Chemistry. 2014; 62(20): 4610
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103 Inhibitory effect of polyphenolic–rich extract from Cola nitida (Kolanut) seed on key enzyme linked to type 2 diabetes and Fe2+ induced lipid peroxidation in rat pancreas in vitro
Ganiyu Oboh,Kate E. Nwokocha,Ayodele J. Akinyemi,Adedayo O. Ademiluyi
Asian Pacific Journal of Tropical Biomedicine. 2014; 4: S405
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104 Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors
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105 Antioxidant, anti-inflammatory, and hypoglycemic effects of the leaf extract from passiflora nitida kunth
Montefusco-Pereira, C.V. and De Carvalho, M.J. and De AraĂşjo Boleti, A.P. and Teixeira, L.S. and Matos, H.R. and Lima, E.S.
Applied Biochemistry and Biotechnology. 2013; 170(6): 1367-1378
106 Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris
Nurul Islam, M. and Jung, H.A. and Sohn, H.S. and Kim, H.M. and Choi, J.S.
Archives of Pharmacal Research. 2013; 36(5): 542-552
107 Mexican antidiabetic herbs: Valuable sources of inhibitors of α-glucosidases
Mata, R. and Cristians, S. and Escandón-Rivera, S. and Juárez-Reyes, K. and Rivero-Cruz, I.
Journal of Natural Products. 2013; 76(3): 468-483
108 Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors
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Nutrients. 2013; 5(3): 663-678
109 Studies on α-glucosidase inhibition and anti-glycation potential of Iris loczyi and Iris unguicularis
Mosihuzzman, M. and Naheed, S. and Hareem, S. and Talib, S. and Abbas, G. and Khan, S.N. and Choudhary, M.I. and Sener, B. and Tareen, R.B. and Israr, M.
Life Sciences. 2013; 92(3): 187-192
110 Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig
Félicien Mushagalusa Kasali,Justin Ntokamunda Kadima,Pius Tshimankinda Mpiana,Koto-te-Nyiwa Ngbolua,Damien Sha-Tshibey Tshibangu
Asian Pacific Journal of Tropical Biomedicine. 2013; 3(11): 841
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111 Antioxidant, Anti-inflammatory, and Hypoglycemic Effects of the Leaf Extract from Passiflora nitida Kunth
Carlos Victor Montefusco-Pereira,Maria José Carvalho,Ana Paula Araújo Boleti,Lorisa Simas Teixeira,Humberto Reis Matos,Emerson Silva Lima
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112 Isolation and identification of a-glucosidase inhibitors from the stem bark of the nutgall tree (Rhus javanica Linné)
Jeong-Yong Cho,Kang-Deok Lee,Sun-Young Park,Won Chul Jeong,Jae-Hak Moon,Kyung-Sik Ham
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113 Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of a-Glucosidases
Rachel Mata,Sol Cristians,Sonia Escandón-Rivera,Krutzkaya Juárez-Reyes,Isabel Rivero-Cruz
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114 Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia
Tsun-Thai Chai,Sanmugapriya Elamparuthi,Ann-Li Yong,Yixian Quah,Hean-Chooi Ong,Fai-Chu Wong
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115 Enzymes Inhibition and Antidiabetic Effect of Isolated Constituents from Dillenia indica
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BioMed Research International. 2013; 2013: 1
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116 Studies on a-glucosidase inhibition and anti-glycation potential of Iris loczyi and Iris unguicularis
Mohmmed Mosihuzzman,Suad Naheed,Sumaira Hareem,Sumaira Talib,Ghulam Abbas,Shamsun Nahar Khan,Muhammad Iqbal Choudhary,Bilge Sener,Rasool Baksh Tareen,Mudassir Israr
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117 Potent a-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris
Md. Nurul Islam,Hyun Ah Jung,Hee Sook Sohn,Hye Mi Kim,Jae Sue Choi
Archives of Pharmacal Research. 2013; 36(5): 542
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118 A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle
Nigel Hoggard,Morven Cruickshank,Kim-Marie Moar,Charles Bestwick,Jens J. Holst,Wendy Russell,Graham Horgan
Journal of Nutritional Science. 2013; 2
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119 A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes
Krishna Bihari Pandeya,Indra Prasad Tripathi,Mahendra Kumar Mishra,Neelesh Dwivedi,Yogesh Pardhi,Arti Kamal,Priyanka Gupta,Nupa Dwivedi,Chinmayi Mishra
International Journal of Organic Chemistry. 2013; 03(01): 1
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120 Effect of Dongchunghacho (Cordyceps militaris) on hyperglycemia and dyslipidemia in type 2 diabetic db/db mice
Ha-Neul Choi,Min-Jung Kang,Soo-Mi Jeong,Min Jeong Seo,Byoung Won Kang,Yong Kee Jeong,Jung-In Kim
Food Science and Biotechnology. 2012; 21(4): 1157
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121 Turmeric (Curcuma longaL.) volatile oil inhibits key enzymes linked to type 2 diabetes
P. C. Lekshmi,Ranjith Arimboor,P. S. Indulekha,A. Nirmala Menon
International Journal of Food Sciences and Nutrition. 2012; 63(7): 832
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122 Berry components inhibit a-glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry
Ashley S. Boath,Derek Stewart,Gordon J. McDougall
Food Chemistry. 2012; 135(3): 929
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123 Inhibition of a-amylase and a-glucosidase activities by ethanolic extract of Telfairia occidentalis (fluted pumpkin) leaf
G Oboh,AJ Akinyemi,AO Ademiluyi
Asian Pacific Journal of Tropical Biomedicine. 2012; 2(9): 733
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124 In vitro inhibition activity of polyphenol-rich extracts from Syzygium aromaticum (L.) Merr. & Perry (Clove) buds against carbohydrate hydrolyzing enzymes linked to type 2 diabetes and Fe2+-induced lipid peroxidation in rat pancreas
Stephen Adeniyi Adefegha,Ganiyu Oboh
Asian Pacific Journal of Tropical Biomedicine. 2012; 2(10): 774
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125 Inhibitory effect of Zn2+ on a-glucosidase: Inhibition kinetics and molecular dynamics simulation
Yan-Fei Zeng,Jinhyuk Lee,Yue-Xiu Si,Li Yan,Tae-Rae Kim,Guo-Ying Qian,Zhi-Rong Lü,Zhuo Ming Ye,Shang-Jun Yin
Process Biochemistry. 2012; 47(12): 2510
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126 Inhibitory effect of Zn2+ on α-glucosidase: Inhibition kinetics and molecular dynamics simulation
Zeng, Y.-F. and Lee, J. and Si, Y.-X. and Yan, L. and Kim, T.-R. and Qian, G.-Y. and LĂĽ, Z.-R. and Ye, Z.M. and Yin, S.-J.
Process Biochemistry. 2012; 47(12): 2510-2517
127 Berry components inhibit α-glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry
Boath, A.S. and Stewart, D. and McDougall, G.J.
Food Chemistry. 2012; 135(3): 929-936
128 Biochemical characterization of α- and β-glucosidases in alimentary canal, salivary glands and haemolymph of the rice green caterpillar, Naranga aenescens M. (Lepidoptera: Noctuidae)
Asadi, A. and Ghadamyari, M. and Sajedi, R.H. and Sendi, J.J. and Tabari, M.
Biologia (Poland). 2012; 67(6): 1186-1194
129 Alpha glucosidase inhibitory effect and enzyme kinetics of coastal medicinal plants
Gurudeeban, S. and Satyavani, K. and Ramanathan, T.
Bangladesh Journal of Pharmacology. 2012; 7(3): 186-191
130 Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes
Lekshmi, P.C. and Arimboor, R. and Indulekha, P.S. and Nirmala Menon, A.
International Journal of Food Sciences and Nutrition. 2012; 63(7): 832-834
131 Effect of bridelia ferruginea (euphorbiaceae) leaf extract on sucrose-induced glucose intolerance in rats
Njamen, D. and Nkeh-Chungag, B.N. and Tsala, E. and Fomum, Z.T. and Mbanya, J.C. and Ngufor, G.F.
Tropical Journal of Pharmaceutical Research. 2012; 11(5): 759-765
132 Antidiabetic activity test by inhibition of α-glucosidaseand phytochemical screening from the most active fraction of buni (Antidesma bunius L.) stem barks and leaves
Elya, B. and Malik, A. and Mahanani, P.I.S. and Loranza, B.
International Journal of PharmTech Research. 2012; 4(4): 1667-1671
133 In vitro inhibition activity of polyphenol-rich extracts from Syzygium aromaticum (L.) Merr. & Perry (Clove) buds against carbohydrate hydrolyzing enzymes linked to type 2 diabetes and Fe 2+-induced lipid peroxidation in rat pancreas
Adefegha, S.A. and Oboh, G.
Asian Pacific Journal of Tropical Biomedicine. 2012; 2(10): 774-781
134 Inhibition of α-amylase and α-glucosidase activities by ethanolic extract of Telfairia occidentalis (fluted pumpkin) leaf
Oboh, G. and Akinyemi, A.J. and Ademiluyi, A.O.
Asian Pacific Journal of Tropical Biomedicine. 2012; 2(9): 733-738
135 Effect of Dongchunghacho (Cordyceps militaris) on hyperglycemia and dyslipidemia in type 2 diabetic db/db mice
Choi, H.-N. and Kang, M.-J. and Jeong, S.-M. and Seo, M.J. and Kang, B.W. and Jeong, Y.K. and Kim, J.-I.
Food Science and Biotechnology. 2012; 21(4): 1157-1162
136 Short and long-term effects of Baccharis articulata on glucose homeostasis
Kappel, V.D. and Pereira, D.F. and Cazarolli, L.H. and Guesser, S.M. and Da Silva, C.H.B. and Schenkel, E.P. and Reginatto, F.H. and Silva, F.R.M.B.
Molecules. 2012; 17(6): 6754-6768
137 Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract
Ali, R.B. and Atangwho, I.J. and Kaur, N. and Abraika, O.S. and Ahmad, M. and Mahmud, R. and Asmawi, M.Z.
Molecules. 2012; 17(5): 4986-5002
138 Biochemical characterization of a- and ß-glucosidases in alimentary canal, salivary glands and haemolymph of the rice green caterpillar, Naranga aenescens M. (Lepidoptera: Noctuidae)
Ameneh Asadi,Mohammad Ghadamyari,Reza Sajedi,Jalal Sendi,Mehrdad Tabari
Biologia. 2012; 67(6)
[Pubmed] | [DOI]


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